Literature DB >> 18239915

Defined salt formulations for the growth of Salinispora tropica strain NPS21184 and the production of salinosporamide A (NPI-0052) and related analogs.

Ginger Tsueng1, Sy Teisan, Kin S Lam.   

Abstract

Salinosporamide A (NPI-0052) is currently produced by a marine actinomycete, Salinispora tropica, via a saline fermentation process using a non-defined, commercially available synthetic sea salt, Instant Ocean. In order to control the consistency of the production of NPI-0052 and related analogs, two chemically defined salt formulations were developed to replace Instant Ocean. A chemically defined sodium-chloride-based salt formulation with similar sodium and chloride contents as in Instant Ocean was found to support higher production of NPI-0052 and a better metabolite production profile for downstream processing than Instant Ocean. A chemically defined sodium-sulfate-based salt formulation with low chloride concentration at 17 mM was found to support a similar NPI-0052 and metabolite production profile as Instant Ocean. The sodium-sulfate-based formulation is a robust formulation for large-scale production process due to its reduced corrosiveness in fermentation as compared with the saline fermentation utilizing Instant Ocean or the sodium-chloride-based salt formulation. The production of NPI-0052 in both chemically defined salt formulations was successfully scaled-up to a 42-l fermentor, indicating that these salt formulations can be used for large-scale manufacturing process.

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Year:  2008        PMID： 18239915     DOI： 10.1007/s00253-008-1358-9

Source DB:  PubMed          Journal:  Appl Microbiol Biotechnol        ISSN： 0175-7598            Impact factor:   4.813


  10 in total

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Authors:  Tobias A M Gulder; Bradley S Moore
Journal:  Angew Chem Int Ed Engl       Date:  2010-12-03       Impact factor: 15.336

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Authors:  Paula C Jimenez; Diego V Wilke; Paola C Branco; Anelize Bauermeister; Paula Rezende-Teixeira; Susana P Gaudêncio; Leticia V Costa-Lotufo
Journal:  Br J Pharmacol       Date:  2019-12-23       Impact factor: 8.739

3.  Molecular networking and pattern-based genome mining improves discovery of biosynthetic gene clusters and their products from Salinispora species.

Authors:  Katherine R Duncan; Max Crüsemann; Anna Lechner; Anindita Sarkar; Jie Li; Nadine Ziemert; Mingxun Wang; Nuno Bandeira; Bradley S Moore; Pieter C Dorrestein; Paul R Jensen
Journal:  Chem Biol       Date:  2015-04-09

Review 4.  The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery.

Authors:  Paul R Jensen; Bradley S Moore; William Fenical
Journal:  Nat Prod Rep       Date:  2015-05       Impact factor: 13.423

Review 5.  Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials.

Authors:  B C Potts; M X Albitar; K C Anderson; S Baritaki; C Berkers; B Bonavida; J Chandra; D Chauhan; J C Cusack; W Fenical; I M Ghobrial; M Groll; P R Jensen; K S Lam; G K Lloyd; W McBride; D J McConkey; C P Miller; S T C Neuteboom; Y Oki; H Ovaa; F Pajonk; P G Richardson; A M Roccaro; C M Sloss; M A Spear; E Valashi; A Younes; M A Palladino
Journal:  Curr Cancer Drug Targets       Date:  2011-03       Impact factor: 3.428

Review 6.  Antitumor compounds from marine actinomycetes.

Authors:  Carlos Olano; Carmen Méndez; José A Salas
Journal:  Mar Drugs       Date:  2009-06-11       Impact factor: 5.118

Review 7.  Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides.

Authors:  Barbara C Potts; Kin S Lam
Journal:  Mar Drugs       Date:  2010-03-25       Impact factor: 5.118

8.  LC-MS-based metabolomics study of marine bacterial secondary metabolite and antibiotic production in Salinispora arenicola.

Authors:  Utpal Bose; Amitha K Hewavitharana; Yi Kai Ng; Paul Nicholas Shaw; John A Fuerst; Mark P Hodson
Journal:  Mar Drugs       Date:  2015-01-07       Impact factor: 5.118

9.  Formulation and Statistical Optimization of Culture Medium for Improved Production of Antimicrobial Compound by Streptomyces sp. JAJ06.

Authors:  Polpass Arul Jose; Kunjukrishnan Kamalakshi Sivakala; Solomon Robinson David Jebakumar
Journal:  Int J Microbiol       Date:  2013-12-23

10.  Genome Mining for Antimicrobial Compounds in Wild Marine Animals-Associated Enterococci.

Authors:  Janira Prichula; Muriel Primon-Barros; Romeu C Z Luz; Ícaro M S Castro; Thiago G S Paim; Maurício Tavares; Rodrigo Ligabue-Braun; Pedro A d'Azevedo; Jeverson Frazzon; Ana P G Frazzon; Adriana Seixas; Michael S Gilmore
Journal:  Mar Drugs       Date:  2021-06-06       Impact factor: 5.118
  10 in total

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