| Literature DB >> 18239856 |
Abstract
Heat shock (HS) response is a universal mechanism of protection against adverse environmental conditions. It is manifested mainly by rapid and robust induction of molecular chaperones and other cytoprotective proteins. In higher eukaryotes the activation of the HS response is mediated by a master regulator, heat shock transcription factor 1 (HSF1). Here we outline recent progress in understanding the early steps in HSF1 activation by heat in the context of existing models of HSF1 regulation.Entities:
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Year: 2008 PMID: 18239856 DOI: 10.1007/s00018-008-7458-y
Source DB: PubMed Journal: Cell Mol Life Sci ISSN: 1420-682X Impact factor: 9.261