Literature DB >> 18239846

Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test.

Piotr Brański1, Agnieszka Palucha, Bernadeta Szewczyk, Joanna M Wierońska, Andrzej Pilc, Gabriel Nowak.   

Abstract

The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.

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Year:  2008        PMID： 18239846     DOI： 10.1007/s00702-008-0023-x

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  7 in total

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