Literature DB >> 18239779

Effects of semax and its Pro-Gly-Pro fragment on calcium homeostasis of neurons and their survival under conditions of glutamate toxicity.

T P Storozhevykh1, G R Tukhbatova, Ya E Senilova, V G Pinelis, L A Andreeva, N F Myasoyedov.   

Abstract

Semax (100 microM) and its Pro-Gly-Pro fragment (20 and 100 microM) delayed the development of calcium dysregulation and reduction of the mitochondrial potential in cultured cerebellar granule cells under conditions of glutamate neurotoxicity. Incubation with these peptides improved neuronal survival by on average 30%. The neuroprotective effect of semax in cerebral ischemia/hypoxia can be due to improvement of mitochondrial resistance to "calcium" stress.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18239779     DOI： 10.1007/s10517-007-0192-x

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  9 in total

1.  Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.

Authors:  Ekaterina V Medvedeva; Veronika G Dmitrieva; Oksana V Povarova; Svetlana A Limborska; Veronika I Skvortsova; Nikolay F Myasoedov; Lyudmila V Dergunova
Journal:  J Mol Neurosci       Date:  2012-07-08       Impact factor: 3.444

2.  The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.

Authors:  Vasily V Stavchansky; Vadim V Yuzhakov; Alexandra Yu Botsina; Veronika I Skvortsova; Lyubov N Bondurko; Marina G Tsyganova; Svetlana A Limborska; Nikolay F Myasoedov; Lyudmila V Dergunova
Journal:  J Mol Neurosci       Date:  2010-07-09       Impact factor: 3.444

3.  Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats.

Authors:  Ekaterina V Medvedeva; Veronika G Dmitrieva; Svetlana A Limborska; Nikolay F Myasoedov; Lyudmila V Dergunova
Journal:  Mol Genet Genomics       Date:  2017-03-02       Impact factor: 3.291

4.  Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia.

Authors:  Veronika G Dmitrieva; Oksana V Povarova; Veronika I Skvortsova; Svetlana A Limborska; Nikolai F Myasoedov; Lyudmila V Dergunova
Journal:  Cell Mol Neurobiol       Date:  2009-07-25       Impact factor: 5.046

5.  Strategy to discover full-length amyloid-beta peptide ligands using high-efficiency microarray technology.

Authors:  Clelia Galati; Natalia Spinella; Lucio Renna; Danilo Milardi; Francesco Attanasio; Michele Francesco Maria Sciacca; Corrado Bongiorno
Journal:  Beilstein J Nanotechnol       Date:  2017-11-20       Impact factor: 3.649

6.  Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats.

Authors:  Ivan B Filippenkov; Vasily V Stavchansky; Alina E Denisova; Vadim V Yuzhakov; Larisa E Sevan'kaeva; Olga Y Sudarkina; Veronika G Dmitrieva; Leonid V Gubsky; Nikolai F Myasoedov; Svetlana A Limborska; Lyudmila V Dergunova
Journal:  Genes (Basel)       Date:  2020-06-22       Impact factor: 4.096

7.  Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.

Authors:  Michele F M Sciacca; Irina Naletova; Maria Laura Giuffrida; Francesco Attanasio
Journal:  ACS Chem Neurosci       Date:  2022-01-26       Impact factor: 4.418

8.  Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion.

Authors:  Olga Yu Sudarkina; Ivan B Filippenkov; Vasily V Stavchansky; Alina E Denisova; Vadim V Yuzhakov; Larisa E Sevan'kaeva; Liya V Valieva; Julia A Remizova; Veronika G Dmitrieva; Leonid V Gubsky; Nikolai F Myasoedov; Svetlana A Limborska; Lyudmila V Dergunova
Journal:  Int J Mol Sci       Date:  2021-06-08       Impact factor: 5.923

9.  The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.

Authors:  Ekaterina V Medvedeva; Veronika G Dmitrieva; Oksana V Povarova; Svetlana A Limborska; Veronika I Skvortsova; Nikolay F Myasoedov; Lyudmila V Dergunova
Journal:  BMC Genomics       Date:  2014-03-24       Impact factor: 3.969
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.