Literature DB >> 18239304

Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents.

Rosaria Gitto1, Eleonora Francica, Giovambattista De Sarro, Francesca Scicchitano, Alba Chimirri.   

Abstract

Following our previous studies in the field of anticonvulsant agents, we planned a one-pot solution-phase parallel synthesis (SPPS) of a small library of new 1,2,3,4-tetrahydroisoquinoline derivatives. The activity against audiogenic seizures in DBA/2 mice of the newly synthesized compounds has also been evaluated.

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Year:  2008        PMID: 18239304     DOI: 10.1248/cpb.56.181

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  1 in total

1.  Methyl trans-(±)-1-oxo-2-phenethyl-3-(thio-phen-2-yl)-1,2,3,4-tetra-hydro-isoquinoline-4-carboxyl-ate.

Authors:  Mehmet Akkurt; Selvi Karaca; Milen G Bogdanov; Meglena I Kandinska; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-05-14
  1 in total

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