| Literature DB >> 1823874 |
C Tharasse-Bloch1, C Chabenat, P Boucly, J Marchand, D Elkharrat, C Boucly-Goester, P Gajdos.
Abstract
Serum levels of ambenonium chloride (AC) were monitored in 4 myasthenic patients. This determination revealed important intraindividual variations (up to 10-fold) over a period of 24 h. Levels varied considerably between different patients (maximum serum concentration of ambenonium chloride ranged from 0.129 to 0.812 micrograms/ml) and no correlation between the daily dose and the AUC was found. These characteristic properties of ambenonium chloride could explain the erratic pattern of bioavailability observed as well as the difficulty in controlling the disease in some patients.Entities:
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Year: 1991 PMID： 1823874 DOI： 10.1007/BF03189975
Source DB: PubMed Journal: Eur J Drug Metab Pharmacokinet ISSN： 0378-7966 Impact factor: 2.441