Literature DB >> 1823650

Sterol composition of nystatin-resistant Candida maltosa mutants.

N P Mikhailova1, E F Sorokoletova, E N Durasova, K A Vyunov, O I Shapovalov.   

Abstract

Composition of sterol fractions of nystatin-resistant Candida maltosa strains was determined. Using UV-spectrometry, TLC and GLC-MS it was demonstrated that resistance to nystatin is connected with the composition alterations of yeast cell sterols. Block of different stages of ergosterol biosynthesis was revealed in some mutants, viz. C-24-transmethylation, delta 8----delta 7-isomerization, 14 alpha-demethylation, C-5(6)-dehydrogenation, reduction of C-14(15) and C-24(28) double bonds.

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Year:  1991        PMID： 1823650     DOI： 10.1007/BF02814494

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  13 in total

1.  Sterol 24(28) methylene reductase in Saccharomyces cerevisiae.

Authors:  W D Neal; L W Parks
Journal:  J Bacteriol       Date:  1977-03       Impact factor: 3.490

2.  The efficacy of various mutagens and polyene antibiotics for the induction and isolation of sterol mutants of Neurospora crassa.

Authors:  M Grindle
Journal:  Mol Gen Genet       Date:  1974-04-09

3.  [Yeast resistance to polyene antibiotics. VII. The interaction of the mutant alleles of the nystatin resistance genes in Saccharomyces cerevisiae].

Authors:  T E Ogorodnikova; N A Sinitskaia; A I Shul'man; N P Mikhaĭlova; K A V'iunov
Journal:  Genetika       Date:  1988-08

4.  Fungicidal inhibitors of ergosterol biosynthesis.

Authors:  B C Baldwin
Journal:  Biochem Soc Trans       Date:  1983-12       Impact factor: 5.407

5.  Some characteristics of nystatin-resistant sterol mutants of Candida albicans.

Authors:  M Pesti; S Paku; E K Novák
Journal:  Acta Microbiol Acad Sci Hung       Date:  1982

6.  [Composition of neutral lipids, phospholipids and their fatty acids in mutant Candida tropicalis D-2 resistant to nystatin].

Authors:  I I Danilenko
Journal:  Izv Akad Nauk SSSR Biol       Date:  1984 Jul-Aug

7.  [The use of various mutagens for induction of nystatin-resistant mutants in Candida maltosa].

Authors:  E N Durasova; N P Mikhaĭlova; E F Sorokoletova; K A V'iunov
Journal:  Mikrobiologiia       Date:  1989 Sep-Oct

8.  Sterol and fatty acid composition of polyene macrolide antibiotic resistant Torulopsis glabrata.

Authors:  M Lomb; M Fryberg; A C Oehlschlager; A M Unrau
Journal:  Can J Biochem       Date:  1975-12

9.  Azasterol inhibition of delta 24-sterol methyltransferase in Saccharomyces cerevisiae.

Authors:  A C Oehlschlager; R H Angus; A M Pierce; H D Pierce; R Srinivasan
Journal:  Biochemistry       Date:  1984-07-31       Impact factor: 3.162

10.  Nystatin-resistant mutants of yeast: alterations in sterol content.

Authors:  R A Woods
Journal:  J Bacteriol       Date:  1971-10       Impact factor: 3.490
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