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Literature DB >> 1823621

Solid phase synthesis of the fibronectin glycopeptide V(Gal beta 3GalNAc alpha)THPGY, its beta analogue, and the corresponding unglycosylated peptide.

B Lüning¹, T Norberg, C Rivera-Baeza, J Tejbrant.

Abstract

The fibronectin fragment VTHPGY and the corresponding glycopeptides V(Gal beta 3GalNAc alpha)THPGY and V(Gal beta 3GalNAc beta)THPGY were synthesized by the FMOC/solid phase approach. FMOC derivatives of threonine, carrying O-linked, peracetylated Gal beta 3GalNAc chains were used for introduction (HOBt-mediated coupling) of the disaccharide moieties.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1991 PMID： 1823621 DOI： 10.1007/BF00769846

Source DB: PubMed Journal: Glycoconj J ISSN： 0282-0080 Impact factor: 2.916

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References

11 in total

1. Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells.

Authors: M Takeuchi; N Inoue; T W Strickland; M Kubota; M Wada; R Shimizu; S Hoshi; H Kozutsumi; S Takasaki; A Kobata
Journal: Proc Natl Acad Sci U S A Date: 1989-10 Impact factor: 11.205

2. The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6. Unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide.

Authors: H Matsuura; K Takio; K Titani; T Greene; S B Levery; M E Salyan; S Hakomori
Journal: J Biol Chem Date: 1988-03-05 Impact factor: 5.157

10. Role of sugar chains in the in vitro biological activity of human erythropoietin produced in recombinant Chinese hamster ovary cells.

Authors: M Takeuchi; S Takasaki; M Shimada; A Kobata
Journal: J Biol Chem Date: 1990-07-25 Impact factor: 5.157

Solid phase synthesis of the fibronectin glycopeptide V(Gal beta 3GalNAc alpha)THPGY, its beta analogue, and the corresponding unglycosylated peptide.

1. Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells.

2. The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6. Unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide.

Review 3. The glycoprotein hormones: recent studies of structure-function relationships.

Review 4. Glycoproteins: what are the sugar chains for?

Review 5. Carbohydrate-specific receptors of the liver.

6. Quantitative monitoring of solid-phase peptide synthesis by the ninhydrin reaction.

7. Synthesis of mono- and disaccharide amino-acid derivatives for use in solid phase peptide synthesis.

8. The role of carbohydrate in recombinant human erythropoietin.

9. The sialylated oligosaccharides of recombinant bovine lutropin modulate hormone bioactivity.

10. Role of sugar chains in the in vitro biological activity of human erythropoietin produced in recombinant Chinese hamster ovary cells.