Literature DB >> 18235993

Micromolar concentration of kynurenic acid in rat small intestine.

D Kuc1, W Zgrajka, J Parada-Turska, T Urbanik-Sypniewska, W A Turski.   

Abstract

Kynurenic acid is an antagonist of glutamate and alpha-7 nicotinic acetylcholine receptors and an agonist of the G: -protein-coupled receptor GPR35, which is predominantly expressed in immune and gastrointestinal tissues. In this study, we report that kynurenic acid is present in the lumen of rat small intestine in micromolar concentration sufficient to affect the GPR35 receptor. Moreover, we show that kynurenic acid can be produced by Escherichia coli. We suggest that kynurenic acid may modulate gastrointestinal function and integrity.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18235993     DOI： 10.1007/s00726-007-0631-z

Source DB:  PubMed          Journal:  Amino Acids        ISSN： 0939-4451            Impact factor:   3.520


  32 in total

1.  Tryptophan Metabolism through the Kynurenine Pathway is Associated with Endoscopic Inflammation in Ulcerative Colitis.

Authors:  M Anthony Sofia; Matthew A Ciorba; Katherine Meckel; Chai K Lim; Gilles J Guillemin; Christopher R Weber; Marc Bissonnette; Joel R Pekow
Journal:  Inflamm Bowel Dis       Date:  2018-06-08       Impact factor: 5.325

2.  The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

3.  Physiological Regulation of Drug Metabolism and Transport: Pregnancy, Microbiome, Inflammation, Infection, and Fasting.

Authors:  Edward T Morgan; Joseph L Dempsey; Sylvie M Mimche; Tracey J Lamb; Supriya Kulkarni; Julia Yue Cui; Hyunyoung Jeong; Angela L Slitt
Journal:  Drug Metab Dispos       Date:  2018-03-07       Impact factor: 3.922

4.  Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline.

Authors:  Troy D Hubbard; Qing Liu; Iain A Murray; Fangcong Dong; Charles Miller; Philip B Smith; Krishne Gowda; Jyh Ming Lin; Shantu Amin; Andrew D Patterson; Gary H Perdew
Journal:  J Proteome Res       Date:  2019-03-04       Impact factor: 4.466

5.  Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

Authors:  Laura Jenkins; Elisa Alvarez-Curto; Kate Campbell; Sabrina de Munnik; Meritxell Canals; Sabine Schlyer; Graeme Milligan
Journal:  Br J Pharmacol       Date:  2011-02       Impact factor: 8.739

6.  Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans.

Authors:  Cornelia Kiank; Jan-Philip Zeden; Solveig Drude; Grazyna Domanska; Gerhard Fusch; Winfried Otten; Christine Schuett
Journal:  PLoS One       Date:  2010-07-28       Impact factor: 3.240

Review 7.  International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coupled receptor list: recommendations for new pairings with cognate ligands.

Authors:  Anthony P Davenport; Stephen P H Alexander; Joanna L Sharman; Adam J Pawson; Helen E Benson; Amy E Monaghan; Wen Chiy Liew; Chidochangu P Mpamhanga; Tom I Bonner; Richard R Neubig; Jean Philippe Pin; Michael Spedding; Anthony J Harmar
Journal:  Pharmacol Rev       Date:  2013-05-17       Impact factor: 25.468

Review 8.  Insulin resistance and dysregulation of tryptophan-kynurenine and kynurenine-nicotinamide adenine dinucleotide metabolic pathways.

Authors:  Gregory Oxenkrug
Journal:  Mol Neurobiol       Date:  2013-06-28       Impact factor: 5.590

9.  Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling.

Authors:  Brett C DiNatale; Iain A Murray; Jennifer C Schroeder; Colin A Flaveny; Tejas S Lahoti; Elizabeth M Laurenzana; Curtis J Omiecinski; Gary H Perdew
Journal:  Toxicol Sci       Date:  2010-01-27       Impact factor: 4.849

10.  Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice.

Authors:  Shukkur M Farooq; Yuning Hou; Hainan Li; Megan O'Meara; Yihan Wang; Chunying Li; Jie-Mei Wang
Journal:  Dig Dis Sci       Date:  2018-07-24       Impact factor: 3.199
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.