BACKGROUND: Coronary flow reserve (CFR) reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac work. METHODS: Forty-one patients who had already undergone coronary angiography were studied. They consisted of 21 haemodialysis patients with no significant left anterior descending coronary artery (LAD) stenosis and 20 non-renal failure patients without LAD stenosis. We performed transthoracic Doppler recording of diastolic coronary flow velocity in the LAD at baseline and after maximal vasodilatation by adenosine triphosphate (ATP) infusion. CFR was defined as the ratio of hyperaemic to basal averaged peak flow velocity. RESULTS: Although the peak coronary velocities during hyperaemia were similar between the two groups, CFR was smaller in haemodialysis (HD) patients than in control subjects (1.96 +/- 04 versus 2.3 +/- 0.5, P = 0.001) due to the higher baseline peak coronary velocities in the former. CONCLUSIONS: The elevated baseline peak coronary velocity may be caused by cardiac hypertrophy and anaemia in HD patients.
BACKGROUND: Coronary flow reserve (CFR) reflects the functional capacity of microcirculation to adapt to blood demand during increased cardiac work. METHODS: Forty-one patients who had already undergone coronary angiography were studied. They consisted of 21 haemodialysis patients with no significant left anterior descending coronary artery (LAD) stenosis and 20 non-renal failurepatients without LAD stenosis. We performed transthoracic Doppler recording of diastolic coronary flow velocity in the LAD at baseline and after maximal vasodilatation by adenosine triphosphate (ATP) infusion. CFR was defined as the ratio of hyperaemic to basal averaged peak flow velocity. RESULTS: Although the peak coronary velocities during hyperaemia were similar between the two groups, CFR was smaller in haemodialysis (HD) patients than in control subjects (1.96 +/- 04 versus 2.3 +/- 0.5, P = 0.001) due to the higher baseline peak coronary velocities in the former. CONCLUSIONS: The elevated baseline peak coronary velocity may be caused by cardiac hypertrophy and anaemia in HDpatients.
Authors: Louis W Wang; Magid A Fahim; Andrew Hayen; Ruth L Mitchell; Laura Baines; Stephen Lord; Jonathan C Craig; Angela C Webster Journal: Cochrane Database Syst Rev Date: 2011-12-07
Authors: Navkaranbir S Bajaj; Amitoj Singh; Wunan Zhou; Ankur Gupta; Kana Fujikura; Christina Byrne; Hendrik J Harms; Michael T Osborne; Paco Bravo; Efstathia Andrikopolou; Sanjay Divakaran; Courtney F Bibbo; Jon Hainer; Hicham Skali; Viviany Taqueti; Michael Steigner; Sharmila Dorbala; David M Charytan; Sumanth D Prabhu; Ron Blankstein; Rahul C Deo; Scott D Solomon; Marcelo F Di Carli Journal: Circulation Date: 2019-11-29 Impact factor: 29.690
Authors: Ashwin Radhakrishnan; Luke C Pickup; Anna M Price; Jonathan P Law; Nicola C Edwards; Richard P Steeds; Charles J Ferro; Jonathan N Townend Journal: Heart Date: 2019-06-25 Impact factor: 5.994