Computer reconstruction of luminal cross-sectional shape from multiple cineangiographic views.

Knowledge of coronary luminal shape, in addition to diameter information as routinely obtained from a cineangiogram, may be useful in assessing lesions which deviate from circular symmetry. We have developed an image analysis system for automated tracking of luminal edges and measurement of diameter form cine frames digitized by a video camera/digitizer interfaced to a Vax 11/780 computer. Between vessel edges, cinedensitometric profiles across the vessel long axis are used to provide a rotationally invariant measure of relative luminal cross-sectional area. A maximum entropy iterative algorithm is used to reconstruct the lumen cross section from a set of projection data consisting of the cinedensitometric profiles from multiple radiographic views. Nonaxisymmetric model coronary lumena, such as a crescent shape and a double lumen simulating a coronary artery dissection, were filmed under cineradiographic conditions similar to clinical exposures. Radiographic views at 10 degrees increments about the model lumen long axis over 360 degrees were available for analysis. Graphic display of reconstructed model lumena indicate that as few as three to five radiographic views may be useful in reconstructing coronary luminal shape.