Literature DB >> 18234497

Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin.

Guang Liang1, Xiaokun Li, Li Chen, Shulin Yang, Xudong Wu, Elaine Studer, Emily Gurley, Phillip B Hylemon, Faqing Ye, Yueru Li, Huiping Zhou.   

Abstract

Curcumin has been extensively studied for its anti-inflammatory activities. However, its potential beneficial effects on various disease preventions and treatments are limited by its unstable structure. The beta-diketone moiety renders curcumin to be rapidly metabolized by aldo-keto reductase in liver. In the present study, a series of curcumin analogues with more stable chemical structures were synthesized and several compounds showed an enhanced ability to inhibit lipopolysaccharide (LPS)-induced TNF-alpha and IL-6 synthesis in macrophages.

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Year:  2008        PMID： 18234497      PMCID： PMC2268908          DOI： 10.1016/j.bmcl.2007.12.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  26 in total

1.  Synthesis and biological analysis of new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer.

Authors:  Hisatsugu Ohori; Hiroyuki Yamakoshi; Masaki Tomizawa; Masatoshi Shibuya; Yuichi Kakudo; Atsuko Takahashi; Shin Takahashi; Satoshi Kato; Takao Suzuki; Chikashi Ishioka; Yoshiharu Iwabuchi; Hiroyuki Shibata
Journal:  Mol Cancer Ther       Date:  2006-10       Impact factor: 6.261

Review 2.  Multiple molecular targets in cancer chemoprevention by curcumin.

Authors:  Rajesh L Thangapazham; Anuj Sharma; Radha K Maheshwari
Journal:  AAPS J       Date:  2006-07-07       Impact factor: 4.009

Review 3.  Inflammation and disease progression.

Authors:  Sriram Krishnamoorthy; Kenneth V Honn
Journal:  Cancer Metastasis Rev       Date:  2006-09       Impact factor: 9.264

Review 4.  Obesity, inflammation, and insulin resistance.

Authors:  Steven E Shoelson; Laura Herrero; Afia Naaz
Journal:  Gastroenterology       Date:  2007-05       Impact factor: 22.682

Review 5.  Curcumin: the Indian solid gold.

Authors:  Bharat B Aggarwal; Chitra Sundaram; Nikita Malani; Haruyo Ichikawa
Journal:  Adv Exp Med Biol       Date:  2007       Impact factor: 2.622

Review 6.  Anti-inflammatory drugs in the 21st century.

Authors:  K D Rainsford
Journal:  Subcell Biochem       Date:  2007

Review 7.  Inflammatory mechanisms of diabetic complications.

Authors:  Michael D Williams; Jerry L Nadler
Journal:  Curr Diab Rep       Date:  2007-06       Impact factor: 4.810

8.  Effects of curcumin on retinal oxidative stress and inflammation in diabetes.

Authors:  Renu A Kowluru; Mamta Kanwar
Journal:  Nutr Metab (Lond)       Date:  2007-04-16       Impact factor: 4.169

Review 9.  Metabolic syndrome, inflammation and atherosclerosis.

Authors:  Rodolfo Paoletti; Chiara Bolego; Andrea Poli; Andrea Cignarella
Journal:  Vasc Health Risk Manag       Date:  2006

10.  Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration.

Authors:  G Garcea; D J L Jones; R Singh; A R Dennison; P B Farmer; R A Sharma; W P Steward; A J Gescher; D P Berry
Journal:  Br J Cancer       Date:  2004-03-08       Impact factor: 7.640
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  32 in total

1.  A novel synthetic mono-carbonyl analogue of curcumin, A13, exhibits anti-inflammatory effects in vivo by inhibition of inflammatory mediators.

Authors:  Yi Wang; Congcong Yu; Yong Pan; Xuyi Yang; Yi Huang; Zhiguo Feng; Xiaokun Li; Shulin Yang; Guang Liang
Journal:  Inflammation       Date:  2012-04       Impact factor: 4.092

2.  Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats.

Authors:  Yong Pan; Yi Wang; Lu Cai; Yuepiao Cai; Jie Hu; Congcong Yu; Jianling Li; Zhiguo Feng; Shulin Yang; Xiaokun Li; Guang Liang
Journal:  Br J Pharmacol       Date:  2012-06       Impact factor: 8.739

Review 3.  Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers.

Authors:  Bharat B Aggarwal; Subash C Gupta; Bokyung Sung
Journal:  Br J Pharmacol       Date:  2013-08       Impact factor: 8.739

4.  (1E,4E)-1,5-Bis(2,4-dimethyl-phen-yl)penta-1,4-dien-3-one.

Authors:  Zhiguo Feng; Junhua Li; Yi Lin
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-29

5.  Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties.

Authors:  Jonathan G Merrell; Shaun W McLaughlin; Lu Tie; Cato T Laurencin; Alex F Chen; Lakshmi S Nair
Journal:  Clin Exp Pharmacol Physiol       Date:  2009-05-19       Impact factor: 2.557

6.  W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway.

Authors:  Yiqun Xia; Bixia Weng; Zhankun Wang; Yanting Kang; Lingyi Shi; Guanqun Huang; Shilong Ying; Xiaojing Du; Qiuxiang Chen; Rong Jin; Jianzhang Wu; Guang Liang
Journal:  Tumour Biol       Date:  2015-10-31

7.  Curcumin analogue, A13, exhibits anti-leukemia effect via inhibiting STAT3.

Authors:  Qiaoyou Weng; Luqing Ren; Lu Guo; Yan Hu; Haixia Zhou; Yuyan Bao; Lingfeng Chen; Guang Liang; Yi Wang; Jichen Ruan
Journal:  Tumour Biol       Date:  2016-01-27

8.  A novel compound C12 inhibits inflammatory cytokine production and protects from inflammatory injury in vivo.

Authors:  Yi Wang; Congcong Yu; Yong Pan; Jianling Li; Yali Zhang; Faqing Ye; Shulin Yang; Hui Zhang; Xiaokun Li; Guang Liang
Journal:  PLoS One       Date:  2011-09-08       Impact factor: 3.240

9.  BDMC33, A curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-κB and MAPK signaling pathways.

Authors:  Ka-Heng Lee; Yuh-Lit Chow; Vidyadaran Sharmili; Faridah Abas; Noorjahan Banu Mohamed Alitheen; Khozirah Shaari; Daud Ahmad Israf; Nordin Haji Lajis; Ahmad Syahida
Journal:  Int J Mol Sci       Date:  2012-03-06       Impact factor: 6.208

10.  Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats.

Authors:  Guo-Xin Hu; Han Lin; Qing-Quan Lian; Shu-Hua Zhou; Jingjing Guo; Hong-Yu Zhou; Yanhui Chu; Ren-Shan Ge
Journal:  PLoS One       Date:  2013-03-22       Impact factor: 3.240
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