Literature DB >> 18231738

Expression of twist gene in primary liver cancer.

Jing Xu1, Xiaoping Chen.   

Abstract

In order to investigate the possibility of overexpression of Twist in primary liver cancer (PLC), the Twist expression was detected by using immunohistochemical analysis and RT-PCR assay in 45 patients with PLC. Control tissues were obtained from 9 patients with liver hemangioma. It was found that in 36 (80.0%) out of 45 PLC patients, cancerous regions showed positive cytoplasm and nucleus staining for Twist with a diffuse pattern. In noncancerous adjacent areas and control liver tissues, the expression of Twist was 57.8% and 22.2% respectively. The results of RT-PCR assay revealed that the expression of Twist was stronger in the cancerous tissues than that in the noncancerous adjacent tissues. It was suggested that the expression of Twist was up-regulated in PLC, which play an important role in the progression of PLC.

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Year:  2007        PMID： 18231738     DOI： 10.1007/s11596-007-0612-1

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  19 in total

1.  DNazyme-mediated cleavage of Twist transcripts and increase in cellular apoptosis.

Authors:  Eleni Hjiantoniou; Sachiko Iseki; James B Uney; Leonidas A Phylactou
Journal:  Biochem Biophys Res Commun       Date:  2003-01-03       Impact factor: 3.575

2.  HOXA5-twist interaction alters p53 homeostasis in breast cancer cells.

Authors:  Ioannis A Stasinopoulos; Yelena Mironchik; Ana Raman; Flonne Wildes; Paul Winnard; Venu Raman
Journal:  J Biol Chem       Date:  2004-11-15       Impact factor: 5.157

3.  The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern.

Authors:  B Thisse; M el Messal; F Perrin-Schmitt
Journal:  Nucleic Acids Res       Date:  1987-04-24       Impact factor: 16.971

4.  Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis.

Authors:  L Li; P Cserjesi; E N Olson
Journal:  Dev Biol       Date:  1995-11       Impact factor: 3.582

5.  Functional analysis of natural mutations in two TWIST protein motifs.

Authors:  Noriko Funato; Stephen R F Twigg; Norihisa Higashihori; Kimie Ohyama; Steven A Wall; Andrew O M Wilkie; Masataka Nakamura
Journal:  Hum Mutat       Date:  2005-06       Impact factor: 4.878

6.  Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation.

Authors:  Louise R Howe; Osamu Watanabe; James Leonard; Anthony M C Brown
Journal:  Cancer Res       Date:  2003-04-15       Impact factor: 12.701

7.  Mutations of the TWIST gene in the Saethre-Chotzen syndrome.

Authors:  V el Ghouzzi; M Le Merrer; F Perrin-Schmitt; E Lajeunie; P Benit; D Renier; P Bourgeois; A L Bolcato-Bellemin; A Munnich; J Bonaventure
Journal:  Nat Genet       Date:  1997-01       Impact factor: 38.330

8.  Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors.

Authors:  N Funato; K Ohtani; K Ohyama; T Kuroda; M Nakamura
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

9.  Deletion of the TWIST gene in a large five-generation family.

Authors:  I M De Heer; A J M Hoogeboom; H J Eussen; J M Vaandrager; A De Klein
Journal:  Clin Genet       Date:  2004-05       Impact factor: 4.438

10.  Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

Authors:  Jing Yang; Sendurai A Mani; Joana Liu Donaher; Sridhar Ramaswamy; Raphael A Itzykson; Christophe Come; Pierre Savagner; Inna Gitelman; Andrea Richardson; Robert A Weinberg
Journal:  Cell       Date:  2004-06-25       Impact factor: 41.582
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