Literature DB >> 18230891

Monogenic human obesity.

I Sadaf Farooqi1.   

Abstract

We and others have identified several single gene defects that disrupt the molecules in the leptinmelanocortin pathway causing severe obesity in humans. In this review, we consider these human monogenic obesity syndromes and discuss how far the characterisation of these patients has informed our understanding of the physiological role of leptin and the melanocortins in the regulation of human body weight and neuroendocrine function.

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Year:  2008        PMID： 18230891     DOI： 10.1159/000115333

Source DB:  PubMed          Journal:  Front Horm Res        ISSN： 0301-3073            Impact factor:   2.606


  42 in total

Review 1.  Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity - but still lots to go.

Authors:  Johannes Hebebrand; Anna-Lena Volckmar; Nadja Knoll; Anke Hinney
Journal:  Obes Facts       Date:  2010-10-15       Impact factor: 3.942

2.  Melanocortin-4-receptor autoantibodies: a new player in obesity.

Authors:  Chandra Mohan; Anil K Agarwal
Journal:  J Clin Endocrinol Metab       Date:  2009-03       Impact factor: 5.958

Review 3.  New targets to treat obesity and the metabolic syndrome.

Authors:  Kathleen A Martin; Mitra V Mani; Arya Mani
Journal:  Eur J Pharmacol       Date:  2015-05-19       Impact factor: 4.432

4.  A segregation analysis of Barrett's esophagus and associated adenocarcinomas.

Authors:  Xiangqing Sun; Robert Elston; Jill Barnholtz-Sloan; Gary Falk; William M Grady; Margaret Kinnard; Sumeet K Mittal; Joseph E Willis; Sanford Markowitz; Wendy Brock; Amitabh Chak
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2010-03-03       Impact factor: 4.254

Review 5.  Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology.

Authors:  Isaac Zike; Tim Xu; Natalie Hong; Jeremy Veenstra-VanderWeele
Journal:  Neuroscience       Date:  2016-09-16       Impact factor: 3.590

Review 6.  Leptin in humans: lessons from translational research.

Authors:  Susann Blüher; Christos S Mantzoros
Journal:  Am J Clin Nutr       Date:  2009-01-28       Impact factor: 7.045

Review 7.  From monogenic to polygenic obesity: recent advances.

Authors:  Anke Hinney; Carla I G Vogel; Johannes Hebebrand
Journal:  Eur Child Adolesc Psychiatry       Date:  2010-02-03       Impact factor: 4.785

8.  Chromosome 16p11.2 deletions: another piece in the genetic puzzle of childhood obesity.

Authors:  Laura Perrone; Pierluigi Marzuillo; Anna Grandone; Emanuele Miraglia del Giudice
Journal:  Ital J Pediatr       Date:  2010-06-11       Impact factor: 2.638

9.  Reduced levels of neurotransmitter-degrading enzyme PRCP promote a lean phenotype. [corrected].

Authors:  Richard D Palmiter
Journal:  J Clin Invest       Date:  2009-07-20       Impact factor: 14.808

10.  Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene.

Authors:  Karine Clément; Béatrice Dubern; Monica Mencarelli; Paul Czernichow; Shosuke Ito; Kazumasa Wakamatsu; Gregory S Barsh; Christian Vaisse; Juliane Leger
Journal:  J Clin Endocrinol Metab       Date:  2008-09-02       Impact factor: 5.958
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