OBJECTIVE: To determine the feasibility and the benefits of combined resistance and interval exercise training on phenotype characteristics and skeletal muscle function in deconditioned, type 2 diabetes (T2D) patients with polyneuropathy. DESIGN: Short-term, single-arm intervention trial. METHODS:Eleven male T2D patients (age: 59.1+/-7.5 years; body mass index: 32.2+/-4.0 kg/m2) performedprogressive resistance and interval exercise training thrice a week for 10 weeks. Besides primary diabetes outcome measures, muscle strength (MUST), maximal workload capacity (Wmax), whole-body peak oxygen uptake (VO2peak) and muscle oxidative capacity (MUOX), intramyocellular lipid (IMCL) and glycogen (IMCG) storage, and systemic inflammation markers were determined before and after training. Daily exogenous insulin requirements (EIR) and historic individualized EIR were gathered and analysed. RESULTS:MUST and Wmax increased with 17% (90% confidence intervals 9-24%) and 14% (6-21) respectively. Furthermore, mean arterial blood pressure declined with 5.5 mmHg (-9.7 to -1.4). EIR dropped with 5.0 IU/d (-11.5 to 1.5) compared with baseline. A decline of respectively -0.7 mmol/l (-2.9 to 1.5) and -147 micromol/l (-296 to 2) in fasting plasma glucose and non-esterified fatty acids concentrations were observed following the intervention, but these were not accompanied by changes in VO2peak, MUOX, IMCL or IMCG, and blood glycolysated haemoglobin, adiponectin, tumor necrosis factor-alpha and/orcholesterol concentrations. CONCLUSION:Short-term resistance and interval exercise training is feasible in deconditioned T2D patients with polyneuropathy and accompanied by moderate improvements in muscle function and blood pressure. Such a specific exercise regimen may provide a better framework for future exercise intervention programmes in the treatment of deconditioned T2D patients.
RCT Entities:
OBJECTIVE: To determine the feasibility and the benefits of combined resistance and interval exercise training on phenotype characteristics and skeletal muscle function in deconditioned, type 2 diabetes (T2D) patients with polyneuropathy. DESIGN: Short-term, single-arm intervention trial. METHODS: Eleven male T2D patients (age: 59.1+/-7.5 years; body mass index: 32.2+/-4.0 kg/m2) performed progressive resistance and interval exercise training thrice a week for 10 weeks. Besides primary diabetes outcome measures, muscle strength (MUST), maximal workload capacity (Wmax), whole-body peak oxygen uptake (VO2peak) and muscle oxidative capacity (MUOX), intramyocellular lipid (IMCL) and glycogen (IMCG) storage, and systemic inflammation markers were determined before and after training. Daily exogenous insulin requirements (EIR) and historic individualized EIR were gathered and analysed. RESULTS: MUST and Wmax increased with 17% (90% confidence intervals 9-24%) and 14% (6-21) respectively. Furthermore, mean arterial blood pressure declined with 5.5 mmHg (-9.7 to -1.4). EIR dropped with 5.0 IU/d (-11.5 to 1.5) compared with baseline. A decline of respectively -0.7 mmol/l (-2.9 to 1.5) and -147 micromol/l (-296 to 2) in fasting plasma glucose and non-esterified fatty acids concentrations were observed following the intervention, but these were not accompanied by changes in VO2peak, MUOX, IMCL or IMCG, and blood glycolysated haemoglobin, adiponectin, tumor necrosis factor-alpha and/or cholesterol concentrations. CONCLUSION: Short-term resistance and interval exercise training is feasible in deconditioned T2D patients with polyneuropathy and accompanied by moderate improvements in muscle function and blood pressure. Such a specific exercise regimen may provide a better framework for future exercise intervention programmes in the treatment of deconditioned T2D patients.
Authors: Christopher S Shaw; Natalie M Cooper; Oliver Shaw; Paulo Salomao; Anton J M Wagenmakers Journal: Eur J Appl Physiol Date: 2011-03-05 Impact factor: 3.078
Authors: Swaytha V Yalamanchi; Kerry J Stewart; Nan Ji; Sherita H Golden; Adrian Dobs; Diane M Becker; Dhananjay Vaidya; Brian G Kral; Rita R Kalyani Journal: Diabetes Res Clin Pract Date: 2016-10-10 Impact factor: 5.602
Authors: Ben D Perry; Marissa K Caldow; Tara C Brennan-Speranza; Melissa Sbaraglia; George Jerums; Andrew Garnham; Chiew Wong; Pazit Levinger; Muhammad Asrar Ul Haq; David L Hare; S Russ Price; Itamar Levinger Journal: Exerc Immunol Rev Date: 2016 Impact factor: 6.308
Authors: Stephen P Juraschek; Julie K Bower; Elizabeth Selvin; Ghanshyam Palamaner Subash Shantha; Ron C Hoogeveen; Christie M Ballantyne; J Hunter Young Journal: Am J Hypertens Date: 2014-07-03 Impact factor: 2.689
Authors: Peter Ahiawodzi; Luc Djousse; Joachim H Ix; Jorge R Kizer; Russell P Tracy; Alice Arnold; Anne Newman; Kenneth J Mukamal Journal: J Am Geriatr Soc Date: 2020-09-22 Impact factor: 5.562