| Literature DB >> 18230418 |
Bruno Amaral Medeiros1, Camila Linhares dos Santos, Raimundo Campos Palheta, Dário Augusto Ferreira de Queiroz, José Ronaldo Vasconcelos da Graça, Armenio Aguiar dos Santos, Francisco Hélio Rola, Aldo Angelo Moreira Lima, Francisco de Assis Aquino Gondim.
Abstract
Spinal cord injury (SCI) is associated with severe autonomic changes, including inhibition of gastrointestinal (GI) motility. GI motility changes are known to affect electrolytes transport and these changes have not been adequately studied after SCI. We studied the ileal permeability to fluid and electrolytes in rats submitted to experimental spinal cord transection (SCT), between T4 and T5, throughout the first week after SCT. SCT increased ileal secretion of Na+ (P<0.05) and decreased the Cl(-) absorption during the first week post SCI (P<0.05). Water transport was also significantly altered, leading to increased water secretion following the Na+ gradient. Ileal secretion of K+ was significantly increased 1 and 7 days after spinal cord injury. To our knowledge, the present findings are the first direct evidence that SCT alters ileal electrolyte transport in rats. Further studies are necessary to evaluate the mechanisms involved in this phenomenon.Entities:
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Year: 2008 PMID： 18230418 DOI： 10.1016/j.autneu.2007.12.003
Source DB: PubMed Journal: Auton Neurosci ISSN： 1566-0702 Impact factor: 3.145