Overview of protein trafficking in the secretory and endocytic pathways.

Proteins migrate from the site of their synthesis to intracellular, surface, or extracellular sites depending on their function. This well-illustrated overview provides an introduction to the pathways of protein trafficking. It includes descriptions of the relevant cellular compartments, modifications associated with the movement of proteins through these compartments, signals used for targeting and translocation, mechanisms for transit between compartments, and methods for sorting proteins.