Literature DB >> 18228207

Role of OPG/RANKL/RANK axis on the vasculature.

A E Papadopouli1, C N Klonaris, S E Theocharis.   

Abstract

Vascular calcification, a degenerative process considered in the past to be a passive procedure, has now been suggested to be related to ossification. Many proteins responsible for bone formation have been identified on the arterial wall. The OPG/RANKL/RANK axis, responsible for ossification and bone mineralization, seems to play a major role in vasculature and atherosclerosis. Mice lacking OPG gene present osteoporosis and arterial calcification, while overexpression of OPG gene leads to osteopetrosis. In the present review the latest knowledge related to the effects of the OPG/RANKL/RANK axis on vasculature, including atherosclerosis, will be analyzed. The clinical significance of circulating OPG and RANKL levels in vascular diseases will also be referred.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18228207     DOI： 10.14670/HH-23.497

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  14 in total

1.  TNFRSF11A and TNFSF11 are associated with age at menarche and natural menopause in white women.

Authors:  Yan Lu; Pengyuan Liu; Robert R Recker; Hong-Wen Deng; Volodymyr Dvornyk
Journal:  Menopause       Date:  2010 Sep-Oct       Impact factor: 2.953

Review 2.  Osteoprotegerin and kidney disease.

Authors:  Alejandra Montañez-Barragán; Isaias Gómez-Barrera; Maria D Sanchez-Niño; Alvaro C Ucero; Liliana González-Espinoza; Alberto Ortiz
Journal:  J Nephrol       Date:  2014-04-23       Impact factor: 3.902

3.  Association of gene polymorphisms in RANKL/RANK/OPG system with hypertension and blood pressure in Chinese women.

Authors:  P Duan; Z-M Wang; J Liu; L-N Wang; Z Yang; P Tu
Journal:  J Hum Hypertens       Date:  2015-03-26       Impact factor: 3.012

4.  Arterial stiffness is not associated with bone parameters in an elderly hyperhomocysteinemic population.

Authors:  S C van Dijk; R T de Jongh; A W Enneman; A C Ham; K M A Swart; J P van Wijngaarden; N L van der Zwaluw; E M Brouwer-Brolsma; N M van Schoor; R A M Dhonukshe-Rutten; P Lips; C P G M de Groot; Y M Smulders; H J Blom; E J Feskens; J M Geleijnse; A H van den Meiracker; F U S Mattace Raso; A G Uitterlinden; M C Zillikens; N van der Velde
Journal:  J Bone Miner Metab       Date:  2015-03-25       Impact factor: 2.626

5.  Deletion of a Distal RANKL Gene Enhancer Delays Progression of Atherosclerotic Plaque Calcification in Hypercholesterolemic Mice.

Authors:  Sohel Shamsuzzaman; Melda Onal; Hillary C St John; J Wesley Pike
Journal:  J Cell Biochem       Date:  2017-05-30       Impact factor: 4.429

Review 6.  Metformin: Is It the Well Wisher of Bone Beyond Glycemic Control in Diabetes Mellitus?

Authors:  Abdul Rahaman Shaik; Prabhjeet Singh; Chandini Shaik; Sunil Kohli; Divya Vohora; Serge Livio Ferrari
Journal:  Calcif Tissue Int       Date:  2021-04-02       Impact factor: 4.333

7.  Correlation of plasma osteoprotegerin (OPG) and receptor activator of the nuclear factor κB ligand (RANKL) levels with clinical risk factors in patients with advanced carotid atherosclerosis.

Authors:  Constantinos Giaginis; Aikaterini Papadopouli; Athina Zira; Athanasios Katsargyris; Christos Klonaris; Stamatios Theocharis
Journal:  Med Sci Monit       Date:  2012-10

8.  Dysregulation of gene expression in a lysosomal storage disease varies between brain regions implicating unexpected mechanisms of neuropathology.

Authors:  Michael K Parente; Ramona Rozen; Cassia N Cearley; John H Wolfe
Journal:  PLoS One       Date:  2012-03-05       Impact factor: 3.240

9.  Distribution of alkaline phosphatase, osteopontin, RANK ligand and osteoprotegerin in calcified human carotid atheroma.

Authors:  Catherine L Higgins; Salim Isbilir; Pamela Basto; Iou Yih Chen; Muthiah Vaduganathan; Periyanan Vaduganathan; Michael J Reardon; Gerald Lawrie; Leif Peterson; Joel D Morrisett
Journal:  Protein J       Date:  2015-10       Impact factor: 2.371

10.  SNP rs2073618 of the osteoprotegerin gene is associated with diabetic retinopathy in Slovenian patients with type 2 diabetes.

Authors:  Sara Mankoč Ramuš; Tina Kumše; Mojca Globočnik Petrovič; Daniel Petrovič; Ines Cilenšek
Journal:  Biomed Res Int       Date:  2013-10-20       Impact factor: 3.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.