A Gambardella1, F Andermann, S Shorvon, E Le Piane, U Aguglia. 1. Institute of Neurology, University Magna Graecia, Catanzaro Viale Europa, Località Germaneto, 88100 Catanzaro, Italy. a.gambardella@isn.cnr.it
Abstract
OBJECTIVE: To describe a more limited and less malignant form of Rasmussen encephalitis (RE). METHODS: Three subjects (all women; 37, 31, and 32 years of age) developed childhood or late onset chronic focal encephalitis, with a relatively nonprogressive form of the disorder. RESULTS: In our patients, clinical features were dominated by partial seizures without marked focal motor deficit and in two with choreo-dystonic movements. The diagnosis of RE was supported by histologic examination and anatomic and functional MRI. CONCLUSIONS: These cases extend the phenotypic presentations of Rasmussen encephalitis and confirm Theodore Rasmussen's suggestion that there may be mild and nonprogressive forms of the disease.
OBJECTIVE: To describe a more limited and less malignant form of Rasmussen encephalitis (RE). METHODS: Three subjects (all women; 37, 31, and 32 years of age) developed childhood or late onset chronic focal encephalitis, with a relatively nonprogressive form of the disorder. RESULTS: In our patients, clinical features were dominated by partial seizures without marked focal motor deficit and in two with choreo-dystonic movements. The diagnosis of RE was supported by histologic examination and anatomic and functional MRI. CONCLUSIONS: These cases extend the phenotypic presentations of Rasmussen encephalitis and confirm Theodore Rasmussen's suggestion that there may be mild and nonprogressive forms of the disease.
Authors: Sara Casciato; Carlo Di Bonaventura; Anna Teresa Giallonardo; Jinane Fattouch; Pier Paolo Quarato; Addolorata Mascia; Alfredo D'Aniello; Andrea Romigi; Vincenzo Esposito; Giancarlo Di Gennaro Journal: Neurosurg Rev Date: 2015-04-16 Impact factor: 3.042