| Literature DB >> 18226907 |
Na Xue1, Xiaochun Yang, Rui Wu, Jing Chen, Qiaojun He, Bo Yang, Xiuyang Lu, Yongzhou Hu.
Abstract
A new series of aryl substituted imidazol-2-one derivatives structurally related to combretastatin A-4 (CA-4) were synthesized and evaluated for their cytotoxic activities in vitro against various human cancer cell lines including MDR cell line. The cytotoxic effects of compounds 7b and 7i proved to be similar to or greater than that of docetaxel. The highly active compound 7b also exhibited excellent inhibitory activity on tumor growth in vivo.Entities:
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Year: 2007 PMID： 18226907 DOI： 10.1016/j.bmc.2007.11.048
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641