| Literature DB >> 18226899 |
Fujiko Konno1, Takuya Arai, Ming-Rong Zhang, Akiko Hatori, Kazuhiko Yanamoto, Masanao Ogawa, Gukuto Ito, Chika Odawara, Tomoteru Yamasaki, Koichi Kato, Kazutoshi Suzuki.
Abstract
Oseltamivir phosphate (Tamiflu, 1.H(3)PO(4) is an orally active anti-influenza drug, which is hydrolyzed by esterase to its carboxylate metabolite Ro 64-0802 (2) with potent activity inhibiting neuraminidase. In this study, for the first time, we synthesized carbon-11-labeled oseltamivir ([(11)C]1) and Ro 64-0802 ([(11)C]2) as two novel positron emission tomography probes and demonstrated that [(11)C]1 had twofold higher radioactivity concentration in the mouse brains than [(11)C]2.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18226899 DOI： 10.1016/j.bmcl.2008.01.037
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823