Ayman A El-Menyar1. 1. Weill Cornell Faculty of Medicine, Doha, Qatar.
Abstract
BACKGROUND: Myocardial dysfunction has been associated with inflammation and cytokine modulation. OBJECTIVES: The study objective was to understand the role of cytokines in the pathophysiology and management of myocardial dysfunction. METHODS: Heart failure has been revisited with revision of the pertinent published articles in the Medline, Scopus, Cochrane Database of Systematic Reviews, and EBSCO Host research. RESULTS: For the proinflammatory cytokines, illumination of this important point requires further diagnostic and therapeutic investigations. Data on chronic heart failure are not so reassuring; therefore, patients with advanced heart failure should not be treated with anticytokines at this time. CONCLUSION: Further studies are warranted to pave the way for introducing cytokine and immunomodulation therapy at the optimal and appropriate time.
BACKGROUND:Myocardial dysfunction has been associated with inflammation and cytokine modulation. OBJECTIVES: The study objective was to understand the role of cytokines in the pathophysiology and management of myocardial dysfunction. METHODS:Heart failure has been revisited with revision of the pertinent published articles in the Medline, Scopus, Cochrane Database of Systematic Reviews, and EBSCO Host research. RESULTS: For the proinflammatory cytokines, illumination of this important point requires further diagnostic and therapeutic investigations. Data on chronic heart failure are not so reassuring; therefore, patients with advanced heart failure should not be treated with anticytokines at this time. CONCLUSION: Further studies are warranted to pave the way for introducing cytokine and immunomodulation therapy at the optimal and appropriate time.
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