OBJECTIVE: The purpose of this study was to evaluate the effectiveness of a human immunodeficiency virus (HIV) rapid testing (RT) program. STUDY DESIGN: From April 13, 2004, to April 13, 2005, pregnant women at 2 high-risk maternity hospitals with no or incomplete HIV testing results (negative tests at <34 weeks, none thereafter) were offered point-of-care RT, with antiretroviral prophylaxis for RT-positive women and their infants. RESULTS: Overall, 89.2% of eligible women (3671/4117) underwent RT, of whom 90.4% received results before delivery. HIV seroprevalence among all women who underwent RT was 2.7% (100/3671 women); among previously untested women, seroprevalence was 6.5% (90/1375 women); the incidence of HIV seroconversion among women with previous negative tests during pregnancy was 0.4% (10/2296 women). After adjustment, the main predictor of receiving RT results after delivery was late admission. Among HIV-exposed infants, 97.9% (92/94) received prophylaxis; 61.7% (58/94) had available follow-up data, and 8.6% (5/58) met criteria for definitive or presumptive HIV infection. CONCLUSION: The RT program achieved timely detection of HIV-infected women in labor with unknown HIV status and effectively prevented perinatal HIV transmission.
OBJECTIVE: The purpose of this study was to evaluate the effectiveness of a human immunodeficiency virus (HIV) rapid testing (RT) program. STUDY DESIGN: From April 13, 2004, to April 13, 2005, pregnant women at 2 high-risk maternity hospitals with no or incomplete HIV testing results (negative tests at <34 weeks, none thereafter) were offered point-of-care RT, with antiretroviral prophylaxis for RT-positive women and their infants. RESULTS: Overall, 89.2% of eligible women (3671/4117) underwent RT, of whom 90.4% received results before delivery. HIV seroprevalence among all women who underwent RT was 2.7% (100/3671 women); among previously untested women, seroprevalence was 6.5% (90/1375 women); the incidence of HIV seroconversion among women with previous negative tests during pregnancy was 0.4% (10/2296 women). After adjustment, the main predictor of receiving RT results after delivery was late admission. Among HIV-exposed infants, 97.9% (92/94) received prophylaxis; 61.7% (58/94) had available follow-up data, and 8.6% (5/58) met criteria for definitive or presumptive HIV infection. CONCLUSION: The RT program achieved timely detection of HIV-infectedwomen in labor with unknown HIV status and effectively prevented perinatal HIV transmission.
Authors: Gerhard B Theron; Mae P Cababasay; Russell B Van Dyke; David E Shapiro; Jeanne Louw; D Heather Watts; Marc Bulterys; Linda M Styer; Robert Maupin Journal: Int J Gynaecol Obstet Date: 2012-11-09 Impact factor: 3.561
Authors: Dmitry M Kissin; Michele G Mandel; Natalia Akatova; Nikolay A Belyakov; Aza G Rakhmanova; Evgeny E Voronin; Galina V Volkova; Alexey A Yakovlev; Denise J Jamieson; Charles Vitek; Joanna Robinson; William C Miller; Susan Hillis Journal: BMC Infect Dis Date: 2011-10-27 Impact factor: 3.090
Authors: Lorainne Tudor Car; Serena Brusamento; Hoda Elmoniry; Michelle H M M T van Velthoven; Utz J Pape; Vivian Welch; Peter Tugwell; Azeem Majeed; Igor Rudan; Josip Car; Rifat Atun Journal: PLoS One Date: 2013-03-06 Impact factor: 3.240