Literature DB >> 18225963

Nonmedical use of prescription stimulants among college students: associations with attention-deficit-hyperactivity disorder and polydrug use.

Amelia M Arria1, Kimberly M Caldeira, Kevin E O'Grady, Kathryn B Vincent, Erin P Johnson, Eric D Wish.   

Abstract

STUDY
OBJECTIVE: To define, among a sample of college students, the nature and extent of nonmedical use of prescription stimulants (NPS), including both overuse and use of someone else's drug, for attention-deficit-hyperactivity disorder (ADHD); to characterize NPS among individuals not medically using a prescription stimulant for ADHD; and to determine whether NPS and overuse of a medically prescribed stimulant for ADHD were independently associated with an increased risk of other illicit drug use and dependence on alcohol and marijuana.
DESIGN: Cross-sectional analysis of personal interview data.
SETTING: Large public university in the mid-Atlantic region. Participants. A cohort of 1253 first-year college students aged 17-20 years.
MEASUREMENTS AND MAIN RESULTS: All students completed a 2-hour personal interview to ascertain medical use and overuse of prescription stimulants, NPS, nonmedical use of other prescription drugs and illicit drug use, and dependence on alcohol and marijuana. Comparisons were made among nonusers, nonmedical users, and medical users of prescription stimulants for ADHD (ADHD+), some of whom overused their drug. Of 1208 students who were not using prescription stimulants medically for ADHD (ADHD-), 218 (18.0%) engaged in NPS. Of 45 ADHD+ students, 12 (26.7%) overused their ADHD drug at least once in their lifetime, and seven (15.6%) nonmedically used someone else's prescription stimulants at least once in their lifetime. Among 225 nonmedical users, NPS was infrequent and mainly associated with studying, although 35 (15.6%) used prescription stimulants to party or to get high. Lifetime NPS was associated with past-year other drug use. Both NPS and overuse of prescribed stimulants for ADHD were independently associated with past-year use of five drugs, holding constant sociodemographic characteristics; NPS was also associated with alcohol and marijuana dependence.
CONCLUSIONS: Physicians should be vigilant for possible overuse and/or diversion of prescription stimulants for ADHD among college students who are medical users of these drugs, as well as the occurrence of illicit drug use with NPS. Initiation of comprehensive drug prevention activities that involve parents as well as college personnel is encouraged to raise awareness of NPS and its association with illicit drug use.

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Year:  2008        PMID: 18225963      PMCID: PMC2906759          DOI: 10.1592/phco.28.2.156

Source DB:  PubMed          Journal:  Pharmacotherapy        ISSN: 0277-0008            Impact factor:   4.705


  31 in total

1.  A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD.

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Journal:  Arch Gen Psychiatry       Date:  1999-12

2.  Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey.

Authors:  Sean Esteban McCabe; John R Knight; Christian J Teter; Henry Wechsler
Journal:  Addiction       Date:  2005-01       Impact factor: 6.526

3.  Medical use, illicit use and diversion of prescription stimulant medication.

Authors:  Sean Esteban McCabe; Christian J Teter; Carol J Boyd
Journal:  J Psychoactive Drugs       Date:  2006-03

4.  Illicit use of prescribed stimulant medication among college students.

Authors:  Kristina M Hall; Melissa M Irwin; Krista A Bowman; William Frankenberger; David C Jewett
Journal:  J Am Coll Health       Date:  2005 Jan-Feb

Review 5.  Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents. Council on Scientific Affairs, American Medical Association.

Authors:  L S Goldman; M Genel; R J Bezman; P J Slanetz
Journal:  JAMA       Date:  1998-04-08       Impact factor: 56.272

6.  Patterns and knowledge of nonmedical use of stimulants among college students.

Authors:  Bronwen C Carroll; Thomas J McLaughlin; Diane R Blake
Journal:  Arch Pediatr Adolesc Med       Date:  2006-05

7.  Medical use, illicit use, and diversion of abusable prescription drugs.

Authors:  Sean Esteban McCabe; Christian J Teter; Carol J Boyd
Journal:  J Am Coll Health       Date:  2006 Mar-Apr

8.  Methylphenidate and dextroamphetamine abuse in substance-abusing adolescents.

Authors:  Robert J Williams; Leslie A Goodale; Michele A Shay-Fiddler; Susan P Gloster; Samuel Y Chang
Journal:  Am J Addict       Date:  2004 Jul-Sep

9.  Prevalence of illicit use and abuse of prescription stimulants, alcohol, and other drugs among college students: relationship with age at initiation of prescription stimulants.

Authors:  Kristy B Kaloyanides; Sean E McCabe; James A Cranford; Christian J Teter
Journal:  Pharmacotherapy       Date:  2007-05       Impact factor: 4.705

10.  Drug treatment of hyperactivity in children.

Authors:  K J Ottenbacher; H M Cooper
Journal:  Dev Med Child Neurol       Date:  1983-06       Impact factor: 5.449

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  57 in total

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Authors:  Amelia M Arria; Robert L DuPont
Journal:  J Addict Dis       Date:  2010-10

2.  Sharing and selling of prescription medications in a college student sample.

Authors:  Laura M Garnier; Amelia M Arria; Kimberly M Caldeira; Kathryn B Vincent; Kevin E O'Grady; Eric D Wish
Journal:  J Clin Psychiatry       Date:  2010-03       Impact factor: 4.384

3.  Intentional misuse of over-the-counter medications, mental health, and polysubstance use in young adults.

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Review 4.  Stimulant prescription cautions: addressing misuse, diversion and malingering.

Authors:  David L Rabiner
Journal:  Curr Psychiatry Rep       Date:  2013-07       Impact factor: 5.285

5.  Medical misuse of controlled medications among adolescents.

Authors:  Sean Esteban McCabe; Brady T West; James A Cranford; Paula Ross-Durow; Amy Young; Christian J Teter; Carol J Boyd
Journal:  Arch Pediatr Adolesc Med       Date:  2011-08

6.  Patterns of concurrent substance use among nonmedical ADHD stimulant users: results from the National Survey on Drug Use and Health.

Authors:  Lian-Yu Chen; Rosa M Crum; Silvia S Martins; Christopher N Kaufmann; Eric C Strain; Ramin Mojtabai
Journal:  Drug Alcohol Depend       Date:  2014-06-10       Impact factor: 4.492

7.  Perceived academic benefit is associated with nonmedical prescription stimulant use among college students.

Authors:  Amelia M Arria; Irene M Geisner; M Dolores Cimini; Jason R Kilmer; Kimberly M Caldeira; Angelica L Barrall; Kathryn B Vincent; Nicole Fossos-Wong; Jih-Cheng Yeh; Isaac Rhew; Christine M Lee; Geetha A Subramaniam; David Liu; Mary E Larimer
Journal:  Addict Behav       Date:  2017-07-14       Impact factor: 3.913

8.  Comparison of the behavioral and cardiovascular effects of intranasal and oral d-amphetamine in healthy human subjects.

Authors:  Joshua A Lile; Shanna Babalonis; Cleeve Emurian; Catherine A Martin; Daniel P Wermeling; Thomas H Kelly
Journal:  J Clin Pharmacol       Date:  2010-07-29       Impact factor: 3.126

9.  Correlates of nonmedical use of stimulants and methamphetamine use in a national sample.

Authors:  Lian-Yu Chen; Eric C Strain; Pierre Kébreau Alexandre; G Caleb Alexander; Ramin Mojtabai; Silvia S Martins
Journal:  Addict Behav       Date:  2014-02-12       Impact factor: 3.913

10.  Dispelling the myth of "smart drugs": cannabis and alcohol use problems predict nonmedical use of prescription stimulants for studying.

Authors:  Amelia M Arria; Holly C Wilcox; Kimberly M Caldeira; Kathryn B Vincent; Laura M Garnier-Dykstra; Kevin E O'Grady
Journal:  Addict Behav       Date:  2012-10-08       Impact factor: 3.913

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