Literature DB >> 18225908

Boron-substituted difluorocyclopropanes: new building blocks of gem-difluorocyclopropanes.

Yasutaka Fujioka1, Hideki Amii.   

Abstract

Cycloaddition of difluorocarbene to alkenyl boronates 3 gave boron-substituted gem-difluorocyclopropanes 2 in stereospecific fashion. Upon treatment with lithium carbenoids, cyclopropyl boronates 2 underwent one-carbon homologation to afford a variety of gem-difluorocyclopropanes in good yields.

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Year:  2008        PMID： 18225908     DOI： 10.1021/ol702851t

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

Review 1.  Decarboxylative fluorination strategies for accessing medicinally- relevant products.

Authors:  Yupu Qiao; Lingui Zhu; Brett R Ambler; Ryan A Altman
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

2.  Cu-Catalyzed Hydroboration of Benzylidenecyclopropanes: Reaction Optimization, (Hetero)Aryl Scope, and Origins of Pathway Selectivity.

Authors:  Jose M Medina; Taeho Kang; Tuğçe G Erbay; Huiling Shao; Gary M Gallego; Shouliang Yang; Michelle Tran-Dubé; Paul F Richardson; Joseph Derosa; Ryan T Helsel; Ryan L Patman; Fen Wang; Christopher P Ashcroft; John F Braganza; Indrawan McAlpine; Peng Liu; Keary M Engle
Journal:  ACS Catal       Date:  2019-10-29       Impact factor: 13.084

3.  Enantioselective homocrotylboration of aliphatic aldehydes.

Authors:  Hongkun Lin; Wenbo Pei; Hao Wang; Kendall N Houk; Isaac J Krauss
Journal:  J Am Chem Soc       Date:  2012-12-26       Impact factor: 15.419

4.  A computational triage approach to the synthesis of novel difluorocyclopentenes and fluorinated cycloheptadienes using thermal rearrangements.

Authors:  David Orr; Jonathan M Percy; Zoë A Harrison
Journal:  Chem Sci       Date:  2016-06-16       Impact factor: 9.825
  4 in total

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