BACKGROUND: The role of apoptosis, and more specifically the Fas pathway, is still unclear in squamous cell laryngeal cancer. MATERIALS AND METHODS: By means of immunohistochemistry, the expression of three genes involved in different pathways of apoptosis (p53, Bcl-2 and Fas) was studied in a series of 45 squamous cell laryngeal cancers from Spanish patients. RESULTS: Of the studied tumors, 25 (55.6%) expressed mutant p53, 22 (48.9%) expressed Bcl-2 and 25 (55.6%) expressed Fas. p53, Bcl-2 and Fas expression were not correlated with each other. The only tested factors associated with significantly better survival of the patients were low tumor stage (p = 0.0074), the absence of metastatic regional nodes (p = 0.0009) and Fas expression (p = 0.029). Fas expression was not correlated with the expression of any other tested parameter. CONCLUSION: The determination of Fas expression in squamous cell laryngeal carcinoma by means of immunohistochemistry using the GM30/CD95 antibody could be of potential use in the clinic.
BACKGROUND: The role of apoptosis, and more specifically the Fas pathway, is still unclear in squamous cell laryngeal cancer. MATERIALS AND METHODS: By means of immunohistochemistry, the expression of three genes involved in different pathways of apoptosis (p53, Bcl-2 and Fas) was studied in a series of 45 squamous cell laryngeal cancers from Spanish patients. RESULTS: Of the studied tumors, 25 (55.6%) expressed mutant p53, 22 (48.9%) expressed Bcl-2 and 25 (55.6%) expressed Fas. p53, Bcl-2 and Fas expression were not correlated with each other. The only tested factors associated with significantly better survival of the patients were low tumor stage (p = 0.0074), the absence of metastatic regional nodes (p = 0.0009) and Fas expression (p = 0.029). Fas expression was not correlated with the expression of any other tested parameter. CONCLUSION: The determination of Fas expression in squamous cell laryngeal carcinoma by means of immunohistochemistry using the GM30/CD95 antibody could be of potential use in the clinic.
Authors: M E Peter; A Hadji; A E Murmann; S Brockway; W Putzbach; A Pattanayak; P Ceppi Journal: Cell Death Differ Date: 2015-02-06 Impact factor: 15.828
Authors: Paulo Bentes de Carvalho-Neto; Marcelo dos Santos; Marcos Brasilino de Carvalho; Ana Maria da Cunha Mercante; Viviane Priscila Pina dos Santos; Patrícia Severino; Eloiza Helena Tajara; Iuri Drumond Louro; Adriana Madeira Álvares da Silva-Conforti Journal: PLoS One Date: 2013-07-19 Impact factor: 3.240