BACKGROUND: The health utilities index (HUI3) is a health measurement instrument based on individuals' preferences for different health states. Breast cancer (BC) is common, with a high proportion of long-term survivors, making evaluation of treatment effects important. Feasibility and responsiveness of HUI3 was compared to the short-form 36 (SF-36) in patients with BC. METHODS: HUI3 and SF-36 were administered eight times: at initial surgical consultation, 1 week before surgery; 1 week, 3, 6, 12, 18, and 24 months after surgery. Effect size, analysis of variance, and Pearson product moment correlations were calculated. BC data were compared to normative values. RESULTS: Eighty-five patients were enrolled. Ninety-one percent of planned assessments were completed. HUI3 showed significant responsiveness (P < 0.01) after surgery and during recovery. HUI3 scores correlated with SF-36 scores. Comparison to normative data demonstrated the significant detrimental effect of BC diagnosis. Results showed long-term effects of treatment on physical health and positive effects on mental/emotional health in BC survivors. CONCLUSION(S): HUI3 was found to be feasible and responsive in our cohort of BC patients. Changes in HUI3 values over time, and compared to normative data, paralleled SF-36 scores. HUI3 is a valuable tool in health-related quality of life and cost-utility studies in patients with BC.
BACKGROUND: The health utilities index (HUI3) is a health measurement instrument based on individuals' preferences for different health states. Breast cancer (BC) is common, with a high proportion of long-term survivors, making evaluation of treatment effects important. Feasibility and responsiveness of HUI3 was compared to the short-form 36 (SF-36) in patients with BC. METHODS: HUI3 and SF-36 were administered eight times: at initial surgical consultation, 1 week before surgery; 1 week, 3, 6, 12, 18, and 24 months after surgery. Effect size, analysis of variance, and Pearson product moment correlations were calculated. BC data were compared to normative values. RESULTS: Eighty-five patients were enrolled. Ninety-one percent of planned assessments were completed. HUI3 showed significant responsiveness (P < 0.01) after surgery and during recovery. HUI3 scores correlated with SF-36 scores. Comparison to normative data demonstrated the significant detrimental effect of BC diagnosis. Results showed long-term effects of treatment on physical health and positive effects on mental/emotional health in BC survivors. CONCLUSION(S): HUI3 was found to be feasible and responsive in our cohort of BC patients. Changes in HUI3 values over time, and compared to normative data, paralleled SF-36 scores. HUI3 is a valuable tool in health-related quality of life and cost-utility studies in patients with BC.
Authors: W M Hopman; T Towheed; T Anastassiades; A Tenenhouse; S Poliquin; C Berger; L Joseph; J P Brown; T M Murray; J D Adachi; D A Hanley; E Papadimitropoulos Journal: CMAJ Date: 2000-08-08 Impact factor: 8.262
Authors: J M Ververs; R M Roumen; A J Vingerhoets; G Vreugdenhil; J W Coebergh; M A Crommelin; E J Luiten; O J Repelaer van Driel; M Schijven; J C Wissing; A C Voogd Journal: Eur J Cancer Date: 2001-05 Impact factor: 9.162
Authors: Matthew M Poggi; David N Danforth; Linda C Sciuto; Sharon L Smith; Seth M Steinberg; David J Liewehr; Cynthia Menard; Marc E Lippman; Allen S Lichter; Rosemary M Altemus Journal: Cancer Date: 2003-08-15 Impact factor: 6.860