| Literature DB >> 1822438 |
F Maggiolo1, G Puricelli, M Dottorini, S Caprioli, W Bianchi, F Suter.
Abstract
The effect of ciprofloxacin, a new broad-spectrum quinolone derivative, on concomitant oral contraceptive steroids has been studied in a double-blind cross-over placebo-controlled randomized trial. Ten healthy women using long-term oral contraceptive steroids received either ciprofloxacin 500 mg BID or placebo during two consecutive cycles. Therapy was continued for seven days from the first day of contraceptive treatment. FSH, LH and oestradiol blood levels were repeatedly determined to monitor contraceptive steroid efficacy. A seven-day treatment with ciprofloxacin did not affect steroid treatment outcome and appears to be safe in women using this contraceptive method.Entities:
Keywords: Antibiotics; Biology; Bleeding; Clinical Research; Clinical Trials; Contraception; Contraceptive Agents; Contraceptive Agents, Estrogen; Contraceptive Agents, Female; Contraceptive Agents, Progestin; Contraceptive Effectiveness; Contraceptive Methods; Contraceptive Mode Of Action; Desogestrel; Developed Countries; Diseases; Double-blind Studies; Drug Interactions; Drugs; Endocrine System; Estradiol; Estrogens; Ethinyl Estradiol; Europe; Family Planning; Follicle Stimulating Hormone; Gestodene; Gonadotropins; Gonadotropins, Pituitary; Hormones; Italy; Levonorgestrel; Luteinizing Hormone; Mediterranean Countries; Metrorrhagia; Oral Contraceptives; Oral Contraceptives, Combined; Ovulation Suppression; Physiology; Research Methodology; Research Report; Signs And Symptoms; Southern Europe; Studies; Treatment
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Year: 1991 PMID： 1822438
Source DB: PubMed Journal: Drugs Exp Clin Res ISSN： 0378-6501