Literature DB >> 1822327

Chromate nephrotoxicity in developing rats. Significance of Cr(VI) reduction in rat kidney tissue.

D Appenroth1, M Friedrich, K H Friese, H Bräunlich.   

Abstract

Chromate reduction was studied in 9000 x g supernatant of renal tissue. It was shown that GSH plays an important role. Additionally, heat-sensitive factor(s) seem to be involved. Age differences in chromate nephrotoxicity parallel differences in chromate reduction in vitro. The lower reductive activity of young rats can be raised to adult values by GSH-addition. Fasting reduces GSH concentration, as well as chromate nephrotoxicity, in vivo.

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Year:  1991        PMID: 1822327

Source DB:  PubMed          Journal:  J Trace Elem Electrolytes Health Dis        ISSN: 0931-2838


  2 in total

1.  The ambiguous effect of ascorbic acid on chromate induced proteinuria in rats.

Authors:  D Appenroth; K Winnefeld; H Schröter; M Rost
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

2.  Mutagenic activity of copper(II) chromate and dichromate complexes with polypyridines.

Authors:  K Szyba; M C Golonka; K Gasiorowski; J Urban
Journal:  Biometals       Date:  1992       Impact factor: 2.949

  2 in total

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