| Literature DB >> 182230 |
Abstract
Menadione in the presence of oxyhemoglobin will accelerate the formation of methemoglobin and result in the generation of superoxide anion. Menadione appears to oxidize slowly ferrohemoglobin to ferrihemoglobin, while forming menadione semiquinone in the process. Menadione semiquinone is known to react with molecular oxygen to yield superoxide anion. The superoxide anion appears to be the source of hydrogen peroxide which accounts for most of the observed methemoglobin formation when hemoglobin is reacted with menadione.Entities:
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Year: 1976 PMID： 182230 DOI： 10.1016/0304-4165(76)90029-5
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002