| Literature DB >> 18222347 |
Beatrijs D Oortwijn1, Jan-Willem Eijgenraam, Maria-Pia Rastaldi, Anja Roos, Mohamed R Daha, Cees van Kooten.
Abstract
IgA nephropathy (IgAN) is characterized by glomerular deposition of IgA, often together with complement components. This deposited IgA is mainly polymeric in nature. Although early studies suggested a role for local complement activation in the development of glomerular injury in IgAN, recent attention has focused on the involvement of the lectin pathway of complement activation in the progression of renal disease in IgAN. In addition, we have found that glomerular secretory IgA deposition may be one of the initiators of local complement activation in the kidney. In the present review we discuss recent developments in this area and provide a model of how mucosal immunity and renal inflammation may be interconnected.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18222347 DOI： 10.1016/j.semnephrol.2007.10.007
Source DB: PubMed Journal: Semin Nephrol ISSN： 0270-9295 Impact factor: 5.299