| Literature DB >> 18221386 |
Manabu Kusakabe1, Kazumi Suzukawa, Toru Nanmoku, Naoshi Obara, Yasushi Okoshi, Harumi Y Mukai, Yuichi Hasegawa, Hiroshi Kojima, Yasushi Kawakami, Haruhiko Ninomiya, Toshiro Nagasawa.
Abstract
Acute promyelocytic leukemia (APL) is characterized by chromosomal rearrangements of 17q21, leading to fusion of the gene-encoding retinoic acid receptor alpha (RARA) with a number of alternative partner genes. Signal transducer and activator of transcription 5 beta (STAT5B) is one of the alternative partners. We report a rare case of APL with STAT5B-RARA fusion transcript and the normal chromosome 17 on G-banding. Administration of all trans-retinoic acid improved disseminated intravascular coagulation without decrease of the leukemia cells in his peripheral blood and bone marrow. The molecular mechanism of fusion between STAT5B and RARA by chromosomal rearrangement is discussed based on the data from genome database. Clinical characteristics of APL with STAT5B-RARA are also discussed.Entities:
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Year: 2008 PMID： 18221386 DOI： 10.1111/j.1600-0609.2008.01042.x
Source DB: PubMed Journal: Eur J Haematol ISSN： 0902-4441 Impact factor: 2.997