Literature DB >> 1822096

Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?

D R McLachlan1, T P Kruck, W J Lukiw, S S Krishnan.   

Abstract

Although the cause of Alzheimer's disease (AD) remains unknown there is mounting evidence that implicates aluminum as a toxic environmental factor of considerable importance. Four independent lines of evidence--laboratory studies of the effects of intracerebral aluminum on the cognitive and memory performance of animals, biochemical studies, epidemiologic studies and the slowing of the progress of the disease with the use of an agent that removes aluminum from the body--now support the concept that aluminum is one of the pathogenic factors in AD. The evidence warrants serious consideration of reducing human exposure to aluminum. We hypothesize that a public health effort to restrict human ingestion of aluminum would reduce the incidence of this common chronic illness in the elderly.

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Year:  1991        PMID: 1822096      PMCID: PMC1335899     

Source DB:  PubMed          Journal:  CMAJ        ISSN: 0820-3946            Impact factor:   8.262


  100 in total

1.  EXPERIMENTAL PRODUCTION OF NEUROFIBRILLARY DEGENERATION. I. LIGHT MICROSCOPIC OBSERVATIONS.

Authors:  I KLATZO; H WISNIEWSKI; E STREICHER
Journal:  J Neuropathol Exp Neurol       Date:  1965-04       Impact factor: 3.685

2.  Pulmonary fibrosis and encephalopathy associated with the inhalation of aluminium dust.

Authors:  A I MCLAUGHLIN; G KAZANTZIS; E KING; R J PORTER; R OWEN
Journal:  Br J Ind Med       Date:  1962-10

3.  Developmental alterations in offspring of female rats orally intoxicated by aluminum lactate at different gestation periods.

Authors:  G Muller; V Bernuzzi; D Desor; M F Hutin; D Burnel; P R Lehr
Journal:  Teratology       Date:  1990-09

4.  Evidence for a phytotoxic hydroxy-aluminum polymer in organic soil horizons.

Authors:  D Hunter; D S Ross
Journal:  Science       Date:  1991-03-01       Impact factor: 47.728

5.  Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes.

Authors:  R A Nixon; J F Clarke; K B Logvinenko; M K Tan; M Hoult; F Grynspan
Journal:  J Neurochem       Date:  1990-12       Impact factor: 5.372

6.  Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Authors:  A Goate; M C Chartier-Harlin; M Mullan; J Brown; F Crawford; L Fidani; L Giuffra; A Haynes; N Irving; L James
Journal:  Nature       Date:  1991-02-21       Impact factor: 49.962

7.  Human neuroblastoma cells treated with aluminium express an epitope associated with Alzheimer's disease neurofibrillary tangles.

Authors:  S P Guy; D Jones; D M Mann; R F Itzhaki
Journal:  Neurosci Lett       Date:  1991-01-02       Impact factor: 3.046

8.  Examination of elongation factor Tu for aluminum fluoride binding sites using fluorescence and 19F-NMR methodologies.

Authors:  T L Hazlett; T Higashijima; D M Jameson
Journal:  FEBS Lett       Date:  1991-01-28       Impact factor: 4.124

9.  A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

Authors:  V M Lee; B J Balin; L Otvos; J Q Trojanowski
Journal:  Science       Date:  1991-02-08       Impact factor: 47.728

10.  DNA Synthesis in Aluminum-Treated Roots of Barley.

Authors:  M Sampson; D Clarkson; D D Davies
Journal:  Science       Date:  1965-06-11       Impact factor: 47.728

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  20 in total

1.  Would decreased aluminum ingestion reduce the incidence of Alzheimer's disease?

Authors:  M H Gault; L Purchase
Journal:  CMAJ       Date:  1992-09-15       Impact factor: 8.262

2.  Alumino-silicate content in calcium supplements derived from various carbonate deposits.

Authors:  B P Bourgoin
Journal:  Bull Environ Contam Toxicol       Date:  1992-06       Impact factor: 2.151

3.  Nanoparticle and iron chelators as a potential novel Alzheimer therapy.

Authors:  Gang Liu; Ping Men; George Perry; Mark A Smith
Journal:  Methods Mol Biol       Date:  2010

4.  The synthesized transporter K16APoE enabled the therapeutic HAYED peptide to cross the blood-brain barrier and remove excess iron and radicals in the brain, thus easing Alzheimer's disease.

Authors:  Zhenyou Zou; Qiqiong Shen; Yanxia Pang; Xin Li; Yongfeng Chen; Xinjuan Wang; Xinhua Luo; Zhongmin Wu; Zhaosheng Bao; Juanli Zhang; Jiawei Liang; Lingjia Kong; Lunan Yan; Lijun Xiong; Tianjun Zhu; Shuaibin Yuan; Miaoyang Wang; Kewei Cai; Yinning Yao; Jianchao Wu; Yuding Jiang; Heng Liu; Jing Liu; Yan Zhou; Qianqian Dong; Wei Wang; Kangjie Zhu; Li Li; Yingjie Lou; Hongdian Wang; Yizi Li; Hong Lin
Journal:  Drug Deliv Transl Res       Date:  2019-02       Impact factor: 4.617

5.  Combined administration of D-galactose and aluminium induces Alzheimer-like lesions in brain.

Authors:  Fei Xiao; Xiao-Guang Li; Xiao-Yu Zhang; Jun-Dai Hou; Lian-Feng Lin; Qin Gao; Huan-Min Luo
Journal:  Neurosci Bull       Date:  2011-06       Impact factor: 5.203

6.  Aluminum and Alzheimer's disease.

Authors:  P Levallois
Journal:  CMAJ       Date:  1995-02-15       Impact factor: 8.262

7.  Phosphorylation sensitizes microtubule-associated protein tau to Al(3+)-induced aggregation.

Authors:  W Li; K K Ma; W Sun; H K Paudel
Journal:  Neurochem Res       Date:  1998-12       Impact factor: 3.996

8.  Aluminum in Neurological and Neurodegenerative Disease.

Authors:  Donald R C McLachlan; Catherine Bergeron; Peter N Alexandrov; William J Walsh; Aileen I Pogue; Maire E Percy; Theodore P A Kruck; Zhide Fang; Nathan M Sharfman; Vivian Jaber; Yuhai Zhao; Wenhong Li; Walter J Lukiw
Journal:  Mol Neurobiol       Date:  2019-01-31       Impact factor: 5.590

9.  Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease.

Authors:  Gang Liu; Ping Men; George Perry; Mark A Smith
Journal:  J Nanoneurosci       Date:  2009-06-01

10.  The study of in vivo quantification of aluminum (Al) in human bone with a compact DD generator-based neutron activation analysis (NAA) system.

Authors:  Patrick Byrne; Farshad Mostafaei; Yingzi Liu; Scott P Blake; David Koltick; Linda H Nie
Journal:  Physiol Meas       Date:  2016-04-19       Impact factor: 2.833

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