| Literature DB >> 18220515 |
Cornelis J Van der Schyf1, Silvia Mandel, Werner J Geldenhuys, Tamar Amit, Yael Avramovich, Hailin Zheng, Mati Fridkin, Shunit Gal, Orly Weinreb, Orit Bar Am, Yotam Sagi, Moussa B H Youdim.
Abstract
Traditionally, drug design programs are focused on optimizing the specificity of lead compounds against a carefully selected drug target. Disappointingly, this approach to discover a "magic bullet" drug has not met with the expected success for CNS disorders. Transcriptomics and proteomic profiling of neurodegenerative diseases have indicated that they are poly-etiological in origin and that the processes leading to neuronal death are multifactorial. An emerging concept is the design of drug ligands that modulate multiple drug targets identified for a particular disease. In this review we explore some examples of multifunctional drugs which may be useful in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.Entities:
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Year: 2007 PMID： 18220515 DOI： 10.2174/156720507783018226
Source DB: PubMed Journal: Curr Alzheimer Res ISSN： 1567-2050 Impact factor: 3.498