OBJECTIVE: To determine the prevalence and predictors of vitamin D insufficiency among black and white adult residents of the southern US. METHODS: A cross-sectional analysis of serum 25(OH)D levels using baseline blood samples from 395 Southern Community Cohort Study (SCCS) participants. Participants were African-American and white adults aged 40-79 who enrolled in the study from 2002-2004. We defined hypovitaminosis D as serum 25(OH)D levels < or = 15 ng/ml. RESULTS: Hypovitaminosis D prevalence was 45% among blacks and 11% among whites. Vitamin D intake from diet and supplements was associated with modest increases in circulating 25(OH)D (0.5-0.7 ng/ml per 100 IU increment), but hypovitaminosis D was found for 32% of blacks with intake > or = 400 IU/day. Body mass index (BMI) was a strong predictor of risk for hypovitaminosis D among black women (OR = 6.5, 95% CI 1.7-25.1 for BMI > or = 30 kg/m(2) vs. 18-24.9 kg/m(2)). UVR exposure estimated by residential location was positively associated with 25(OH)D levels among all groups except white women. CONCLUSIONS: Hypovitaminosis D was present in a substantial proportion of the African-American population studied, even in the South and among those meeting recommended dietary guidelines. Vitamin D should continue to be a studied target for ameliorating racial cancer disparities in the US.
OBJECTIVE: To determine the prevalence and predictors of vitamin Dinsufficiency among black and white adult residents of the southern US. METHODS: A cross-sectional analysis of serum 25(OH)D levels using baseline blood samples from 395 Southern Community Cohort Study (SCCS) participants. Participants were African-American and white adults aged 40-79 who enrolled in the study from 2002-2004. We defined hypovitaminosis D as serum 25(OH)D levels < or = 15 ng/ml. RESULTS: Hypovitaminosis D prevalence was 45% among blacks and 11% among whites. Vitamin D intake from diet and supplements was associated with modest increases in circulating 25(OH)D (0.5-0.7 ng/ml per 100 IU increment), but hypovitaminosis D was found for 32% of blacks with intake > or = 400 IU/day. Body mass index (BMI) was a strong predictor of risk for hypovitaminosis D among black women (OR = 6.5, 95% CI 1.7-25.1 for BMI > or = 30 kg/m(2) vs. 18-24.9 kg/m(2)). UVR exposure estimated by residential location was positively associated with 25(OH)D levels among all groups except white women. CONCLUSIONS: Hypovitaminosis D was present in a substantial proportion of the African-American population studied, even in the South and among those meeting recommended dietary guidelines. Vitamin D should continue to be a studied target for ameliorating racial cancer disparities in the US.
Authors: Lisa B Signorello; Scott M Williams; Wei Zheng; Jeffrey R Smith; Jirong Long; Qiuyin Cai; Margaret K Hargreaves; Bruce W Hollis; William J Blot Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-07-20 Impact factor: 4.254
Authors: Toni J Lewis; William D Dupont; Kathleen M Egan; Corey D Jones; Anthony C Disher; William R Riddle; Alecia Malin Fair Journal: J Health Care Poor Underserved Date: 2010-02
Authors: Stephen A Haddad; Edward A Ruiz-Narváez; Yvette C Cozier; Hanna Gerlovin; Lynn Rosenberg; Julie R Palmer Journal: Am J Epidemiol Date: 2018-07-01 Impact factor: 4.897
Authors: Jean Y Tang; Teresa Fu; Christopher Lau; Dennis H Oh; Daniel D Bikle; Maryam M Asgari Journal: J Am Acad Dermatol Date: 2012-11 Impact factor: 11.527
Authors: Marjorie L McCullough; Stephanie J Weinstein; D Michal Freedman; Kathy Helzlsouer; W Dana Flanders; Karen Koenig; Laurence Kolonel; Francine Laden; Loic Le Marchand; Mark Purdue; Kirk Snyder; Victoria L Stevens; Rachael Stolzenberg-Solomon; Jarmo Virtamo; Gong Yang; Kai Yu; Wei Zheng; Demetrius Albanes; Jason Ashby; Kimberly Bertrand; Hui Cai; Yu Chen; Lisa Gallicchio; Edward Giovannucci; Eric J Jacobs; Susan E Hankinson; Patricia Hartge; Virginia Hartmuller; Chinonye Harvey; Richard B Hayes; Ronald L Horst; Xiao-Ou Shu Journal: Am J Epidemiol Date: 2010-06-18 Impact factor: 4.897