Literature DB >> 18219224

Mitochondrial localization of human recombinant adenovirus: from evolution to gene therapy.

Salvatore Alesci1, Mones Abu-Asab, Shiromi M Perera, Maria Tsokos, John C Morris, Karel Pacak.   

Abstract

Mitochondrial research has influenced concepts in anthropology, human physiology and pathophysiology. We present here direct evidence that human recombinant viruses can localize in mitochondria to disrupt their integrity. This finding, while opening new perspectives in viral gene therapy, may provide new insights into the pathogenesis, prevention and treatment of viral diseases. In addition, it may advance the current understanding of cell evolution. (c) 2008 S. Karger AG, Basel

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Year:  2008        PMID： 18219224      PMCID： PMC2279234          DOI： 10.1159/000113065

Source DB:  PubMed          Journal:  Neuroimmunomodulation        ISSN： 1021-7401            Impact factor:   2.492


  6 in total

1.  Gene therapy death prompts review of adenovirus vector.

Authors:  E Marshall
Journal:  Science       Date:  1999-12-17       Impact factor: 47.728

Review 2.  Mitochondrial evolution.

Authors:  M W Gray; G Burger; B F Lang
Journal:  Science       Date:  1999-03-05       Impact factor: 47.728

3.  Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice.

Authors:  J F Powers; M J Evinger; P Tsokas; S Bedri; J Alroy; M Shahsavari; A S Tischler
Journal:  Cell Tissue Res       Date:  2000-12       Impact factor: 5.249

4.  Neurotransmitters and neuropeptides in the differential regulation of steroidogenesis in adrenocortical-chromaffin co-cultures.

Authors:  M Ehrhart-Bornstein; A Haidan; S Alesci; S R Bornstein
Journal:  Endocr Res       Date:  2000-11       Impact factor: 1.720

5.  Adenoviral vectors can impair adrenocortical steroidogenesis: clinical implications for natural infections and gene therapy.

Authors:  Salvatore Alesci; Walter J Ramsey; Stefan R Bornstein; George P Chrousos; Peter J Hornsby; Salvatore Benvenga; Francesco Trimarchi; Monika Ehrhart-Bornstein
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

Review 6.  The challenge of emerging and re-emerging infectious diseases.

Authors:  David M Morens; Gregory K Folkers; Anthony S Fauci
Journal:  Nature       Date:  2004-07-08       Impact factor: 49.962
  6 in total
  1 in total

1.  Characterization of an animal model of aggressive metastatic pheochromocytoma linked to a specific gene signature.

Authors:  Lucia Martiniova; Edwin W Lai; Abdel G Elkahloun; Mones Abu-Asab; Andrea Wickremasinghe; Daniel C Solis; Shiromi M Perera; Thanh-Truc Huynh; Irina A Lubensky; Arthur S Tischler; Richard Kvetnansky; Salvatore Alesci; John C Morris; Karel Pacak
Journal:  Clin Exp Metastasis       Date:  2009-01-25       Impact factor: 5.150
  1 in total

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