Literature DB >> 18218641

Hepatitis B virus escape mutants induced by antiviral therapy.

Julie Sheldon1, Vincent Soriano.   

Abstract

The hepatitis B virus (HBV) polymerase and envelope genes overlap in such a way that resistance mutations to antiviral agents in the reverse transcriptase gene may affect the antigenicity of the HBV surface antigen. Mutant viruses may escape serological diagnosis using specific anti-HBV surface antigen antibodies, causing occult forms of chronic hepatitis B. Moreover, these HBV strains may evade vaccine protection, representing a public health challenge. Thus, the circulation of HBVs encoding envelope mutations selected by antiviral agents requires close monitoring.

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Year:  2008        PMID： 18218641     DOI： 10.1093/jac/dkn014

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  42 in total

1.  Mutations in the S gene region of hepatitis B virus genotype D in Golestan Province-Iran.

Authors:  Abdolvahab Moradi; Sareh Zhand; Amir Ghaemi; Naeme Javid; Alijan Tabarraei
Journal:  Virus Genes       Date:  2012-01-25       Impact factor: 2.332

Review 2.  Lamivudine resistance in children with chronic hepatitis B.

Authors:  Erhun Kasırga
Journal:  World J Hepatol       Date:  2015-04-28

3.  Reactivation of resolved infection with the hepatitis B virus immune escape mutant G145R during dasatinib treatment for chronic myeloid leukemia.

Authors:  Toshihiko Ando; Kensuke Kojima; Hiroshi Isoda; Yuichiro Eguchi; Takashi Honda; Masatoshi Ishigami; Shinya Kimura
Journal:  Int J Hematol       Date:  2015-04-05       Impact factor: 2.490

4.  Molecular characterization of intrahepatic and extrahepatic hepatitis B virus (HBV) reservoirs in patients on suppressive antiviral therapy.

Authors:  C S Coffin; P M Mulrooney-Cousins; M G Peters; G van Marle; J P Roberts; T I Michalak; N A Terrault
Journal:  J Viral Hepat       Date:  2011-06       Impact factor: 3.728

5.  Epidemiology of HBV S-gene mutants in the Liguria Region, Italy: Implications for surveillance and detection of new escape variants.

Authors:  Laura Sticchi; Patrizia Caligiuri; Roberto Cacciani; Cristiano Alicino; Bianca Bruzzone
Journal:  Hum Vaccin Immunother       Date:  2013-01-07       Impact factor: 3.452

Review 6.  Overview of hepatitis B virus mutations and their implications in the management of infection.

Authors:  Patrizia Caligiuri; Rita Cerruti; Giancarlo Icardi; Bianca Bruzzone
Journal:  World J Gastroenterol       Date:  2016-01-07       Impact factor: 5.742

7.  Global control of hepatitis B virus: does treatment-induced antigenic change affect immunization?

Authors:  C John Clements; Ben Coghlan; Mick Creati; Stephen Locarnini; Richard S Tedder; Joseph Torresi
Journal:  Bull World Health Organ       Date:  2009-10-23       Impact factor: 9.408

8.  Differential impact of immune escape mutations G145R and P120T on the replication of lamivudine-resistant hepatitis B virus e antigen-positive and -negative strains.

Authors:  Samad Amini-Bavil-Olyaee; Mihael Vucur; Tom Luedde; Christian Trautwein; Frank Tacke
Journal:  J Virol       Date:  2009-11-04       Impact factor: 5.103

9.  Hepatitis B, C, and D and HIV infections among immigrants from Equatorial Guinea living in Spain.

Authors:  Pablo Rivas; María D Herrero; Eva Poveda; Antonio Madejón; Ana Treviño; Maite Gutiérrez; Concepción Ladrón de Guevara; Mar Lago; Carmen de Mendoza; Vincent Soriano; Sabino Puente
Journal:  Am J Trop Med Hyg       Date:  2013-01-21       Impact factor: 2.345

10.  A function essential to viral entry underlies the hepatitis B virus "a" determinant.

Authors:  Jessica Salisse; Camille Sureau
Journal:  J Virol       Date:  2009-07-01       Impact factor: 5.103
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