| Literature DB >> 18217885 |
A Poleggi1, A Bizzarro, A Acciarri, P Antuono, S Bagnoli, E Cellini, G Dal Forno, C Giannattasio, A Lauria, M G Matera, B Nacmias, M Puopolo, D Seripa, S Sorbi, D R Wekstein, M Pocchiari, C Masullo.
Abstract
Codon 129 polymorphism of the prion protein gene represents a major genetic risk factor for Creutzfeldt-Jakob disease (CJD). Both CJD and Alzheimer's disease (AD) are brain amyloidoses and it would be possible that codon 129 polymorphism plays a role in the susceptibility to AD. In order to investigate this polymorphism in AD the distribution of polymorphic codon 129 of the PRNP gene in 194 probable AD and 124 controls selected in Italy and 109 neuropathologically verified AD and 58 matched controls recruited in the USA was studied. No significant association was found for the PRNP polymorphism in AD compared to controls either in Probable or in Definite AD series even after stratification for APOE polymorphism. This study does not support a role of PRNP polymorphism as a susceptibility factor for AD.Entities:
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Year: 2008 PMID： 18217885 DOI： 10.1111/j.1468-1331.2007.02021.x
Source DB: PubMed Journal: Eur J Neurol ISSN： 1351-5101 Impact factor: 6.089