Sabine J Roza1, Pol A C VAN Lier1, Vincent W V Jaddoe1, Eric A P Steegers1, Henriette A Moll1, Johan P Mackenbach1, Albert Hofman1, Frank C Verhulst1, Henning Tiemeier2. 1. Drs. Roza and Jaddoe are with the Generation R Study Group; Drs. Roza, Verhulst, and Tiemeier are with the Department of Child and Adolescent Psychiatry; Drs. Jaddoe, Hofman, and Tiemeier are with the Department of Epidemiology and Biostatistics; Drs. Jaddoe and Moll are with the Department of Pediatrics; Dr. Steegers is with the Department of Obstetrics and Gynecology; Dr. Mackenbach is with the Department of Public Health; and Dr. van Lier is with the Department of Developmental Psychology, Vrije Universiteit Amsterdam. 2. Drs. Roza and Jaddoe are with the Generation R Study Group; Drs. Roza, Verhulst, and Tiemeier are with the Department of Child and Adolescent Psychiatry; Drs. Jaddoe, Hofman, and Tiemeier are with the Department of Epidemiology and Biostatistics; Drs. Jaddoe and Moll are with the Department of Pediatrics; Dr. Steegers is with the Department of Obstetrics and Gynecology; Dr. Mackenbach is with the Department of Public Health; and Dr. van Lier is with the Department of Developmental Psychology, Vrije Universiteit Amsterdam.. Electronic address: h.tiemeier@erasmusmc.nl.
Abstract
OBJECTIVE: To determine whether intrauterine growth trajectories are associated with temperamental difficulties in infancy. METHOD: The Generation R Study is a population-based cohort study from fetal life onward. Size at different time points during gestation and growth trajectories, calculated on the basis of repeatedly measured fetal growth characteristics, were related to temperamental dimensions, assessed with the Infant Behavior Questionnaire-Revised, in 3,792 infants age 6 months. RESULTS: Birth weight, adjusted for gestational age, was negatively associated with activity level and duration of orienting. These associations disappeared after additional adjustment for maternal height, age, educational level, and national origin. Similarly, the negative associations between intrauterine total body weight gain and falling reactivity and activity level diminished after correction for maternal and child characteristics. After full adjustment, reduced fetal weight gain was only related to prolonged duration of orienting. Children scored 0.38 (95% confidence interval 0.09-0.68) points higher on duration of orienting per SD decrease in total body weight gain from mid-pregnancy to birth. CONCLUSIONS: After controlling for several genetic and socioeconomic status related factors, we found little indication of an association between intrauterine growth trajectories and temperamental difficulties in infants.
OBJECTIVE: To determine whether intrauterine growth trajectories are associated with temperamental difficulties in infancy. METHOD: The Generation R Study is a population-based cohort study from fetal life onward. Size at different time points during gestation and growth trajectories, calculated on the basis of repeatedly measured fetal growth characteristics, were related to temperamental dimensions, assessed with the Infant Behavior Questionnaire-Revised, in 3,792 infants age 6 months. RESULTS: Birth weight, adjusted for gestational age, was negatively associated with activity level and duration of orienting. These associations disappeared after additional adjustment for maternal height, age, educational level, and national origin. Similarly, the negative associations between intrauterine total body weight gain and falling reactivity and activity level diminished after correction for maternal and child characteristics. After full adjustment, reduced fetal weight gain was only related to prolonged duration of orienting. Children scored 0.38 (95% confidence interval 0.09-0.68) points higher on duration of orienting per SD decrease in total body weight gain from mid-pregnancy to birth. CONCLUSIONS: After controlling for several genetic and socioeconomic status related factors, we found little indication of an association between intrauterine growth trajectories and temperamental difficulties in infants.
Authors: Pauline W Jansen; Hein Raat; Johan P Mackenbach; Vincent W V Jaddoe; Albert Hofman; Frank C Verhulst; Henning Tiemeier Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2008-07-28 Impact factor: 4.328
Authors: Elena Netsi; Marinus H van IJzendoorn; Marian J Bakermans-Kranenburg; Katharina Wulff; Pauline W Jansen; Vincent W V Jaddoe; Frank C Verhulst; Henning Tiemeier; Paul G Ramchandani Journal: J Dev Behav Pediatr Date: 2015 Jul-Aug Impact factor: 2.225
Authors: Vincent W V Jaddoe; Cock M van Duijn; Albert J van der Heijden; Johan P Mackenbach; Henriëtte A Moll; Eric A P Steegers; Henning Tiemeier; Andre G Uitterlinden; Frank C Verhulst; Albert Hofman Journal: Eur J Epidemiol Date: 2010-10-22 Impact factor: 8.082
Authors: E M B Horrevorts; A van Grieken; S M L Broeren; R Bannink; M B R Bouwmeester-Landweer; E Hafkamp-de Groen; Hein Raat Journal: BMC Psychol Date: 2015-12-30
Authors: Jolien Rijlaarsdam; Henning Tiemeier; Ank P Ringoot; Masha Y Ivanova; Vincent W V Jaddoe; Frank C Verhulst; Sabine J Roza Journal: Eur Child Adolesc Psychiatry Date: 2015-11-20 Impact factor: 4.785