PURPOSE: To report a non-contact lens wearer with persistent Acanthamoeba organisms in the cornea after being treated with medical therapy that included topical chlorhexidine as 1 agent for 1 year. METHODS: A 53-year-old man with Acanthamoeba keratitis was treated with medical therapy for >1 year, followed by a penetrating keratoplasty. RESULTS: Histopathologic examination of the keratoplasty specimen revealed viable-appearing Acanthamoeba cysts and trophozoites within the deep corneal stroma in a focus of corneal scarring. CONCLUSIONS: The use of chlorhexidine as 1 agent in the medical management of Acanthamoeba keratitis may not eradicate the organisms.
PURPOSE: To report a non-contact lens wearer with persistent Acanthamoeba organisms in the cornea after being treated with medical therapy that included topical chlorhexidine as 1 agent for 1 year. METHODS: A 53-year-old man with Acanthamoeba keratitis was treated with medical therapy for >1 year, followed by a penetrating keratoplasty. RESULTS: Histopathologic examination of the keratoplasty specimen revealed viable-appearing Acanthamoeba cysts and trophozoites within the deep corneal stroma in a focus of corneal scarring. CONCLUSIONS: The use of chlorhexidine as 1 agent in the medical management of Acanthamoeba keratitis may not eradicate the organisms.
Authors: Carmen María Martín-Navarro; Jacob Lorenzo-Morales; Rubén P Machin; Atteneri López-Arencibia; José Manuel García-Castellano; Isabel de Fuentes; Brendan Loftus; Sutherland K Maciver; Basilio Valladares; José E Piñero Journal: Antimicrob Agents Chemother Date: 2012-10-31 Impact factor: 5.191
Authors: P López-Barona; C Verdú-Expósito; T Martín-Pérez; N Gómez-Casanova; T Lozano-Cruz; P Ortega; R Gómez; J Pérez-Serrano; I Heredero-Bermejo Journal: Sci Rep Date: 2022-09-02 Impact factor: 4.996
Authors: Lenu B Fakae; Carl W Stevenson; Xing-Quan Zhu; Hany M Elsheikha Journal: Int J Parasitol Drugs Drug Resist Date: 2020-06-02 Impact factor: 4.077