Literature DB >> 18216513

Should excised keloid scars be sent for routine histologic analysis?

Nadim Gulamhuseinwala1, Simon Mackey, Peter Meagher, Barry Powell.   

Abstract

INTRODUCTION: Keloid scarring is a clinical diagnosis, usually preceded by a history of localized trauma. Significant variation exists as to whether excised specimens are sent for routine histologic analysis. We aimed to review the histology of all clinically diagnosed keloids at our unit.
METHODS: All keloids diagnosed clinically and excised were identified between April 1995 and April 2006. The subsequent histology results were analyzed.
RESULTS: Five hundred sixty-eight specimens were sent for pathologic investigation over an 11-year period. Four hundred fifty-eight (81%) were reported as "keloid," 60 (11%) as "acne keloidalis," 35 (6%) as "hypertrophic scar," and 14 (2%) as "normal scar." There were no reported malignancies or dysplasias. DISCUSSION: These histology results suggest that, given a good clinical suspicion of keloid, it may be unnecessary to send specimens at excision for routine histology.

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Mesh:

Year:  2008        PMID: 18216513     DOI: 10.1097/SAP.0b013e318056d6cc

Source DB:  PubMed          Journal:  Ann Plast Surg        ISSN: 0148-7043            Impact factor:   1.539


  6 in total

1.  Downregulated cytotoxic CD8+ T-cell identifies with the NKG2A-soluble HLA-E axis as a predictive biomarker and potential therapeutic target in keloids.

Authors:  Heng Xu; Zhu Zhu; Jian Hu; Jiawei Sun; Yan Wo; Xianshu Wang; Hongzhi Zou; Bin Li; Yixin Zhang
Journal:  Cell Mol Immunol       Date:  2022-01-17       Impact factor: 22.096

2.  Does Keloid Histology Influence Recurrence?

Authors:  Ferdinand W Nangole; Kelsey Ouyang; Omu Anzala; Julius Ogeng'o; George W Agak; Daniel Zuriel
Journal:  Am J Dermatopathol       Date:  2021-09-01       Impact factor: 1.319

3.  Complete excision of proliferating core in auricular keloids significantly reduces local recurrence: A prospective study.

Authors:  Yosep Chong; Chan Woo Kim; Yong Sung Kim; Choong Hyun Chang; Tae Hwan Park
Journal:  J Dermatol       Date:  2017-10-30       Impact factor: 4.005

Review 4.  The Keloid Disorder: Heterogeneity, Histopathology, Mechanisms and Models.

Authors:  Grace C Limandjaja; Frank B Niessen; Rik J Scheper; Susan Gibbs
Journal:  Front Cell Dev Biol       Date:  2020-05-26

Review 5.  Hypertrophic scars and keloids: Overview of the evidence and practical guide for differentiating between these abnormal scars.

Authors:  Grace C Limandjaja; Frank B Niessen; Rik J Scheper; Susan Gibbs
Journal:  Exp Dermatol       Date:  2020-07-06       Impact factor: 3.960

Review 6.  The Most Current Algorithms for the Treatment and Prevention of Hypertrophic Scars and Keloids: A 2020 Update of the Algorithms Published 10 Years Ago.

Authors:  Rei Ogawa
Journal:  Plast Reconstr Surg       Date:  2022-01-01       Impact factor: 4.730

  6 in total

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