Literature DB >> 18216302

A longitudinal study of drivers with Alzheimer disease.

B R Ott1, W C Heindel, G D Papandonatos, E K Festa, J D Davis, L A Daiello, J C Morris.   

Abstract

OBJECTIVE: The goal of this study was to define the natural progression of driving impairment in persons who initially have very mild to mild dementia.
METHODS: We studied 128 older drivers, including 84 with early Alzheimer disease (AD) and 44 age-matched control subjects without cognitive impairment. Subjects underwent repeated assessments of their cognitive, neurologic, visual, and physical function over 3 years. Self-reports of driving accidents and traffic violations were supplemented by reports from family informants and state records. Within 2 weeks of the office evaluation, subjects were examined by a professional driving instructor on a standardized road test.
RESULTS: At baseline, subjects with AD had experienced more accidents and performed more poorly on the road test, compared to controls. Over time, both groups declined in driving performance on the road test, with subjects with AD declining more than controls. Survival analysis indicated that while the majority of subjects with AD passed the examination at baseline, greater severity of dementia, increased age, and lower education were associated with higher rates of failure and marginal performance.
CONCLUSIONS: This study confirms previous reports of potentially hazardous driving in persons with early Alzheimer disease, but also indicates that some individuals with very mild dementia can continue to drive safely for extended periods of time. Regular follow-up assessments, however, are warranted in those individuals.

Entities:  

Mesh:

Year:  2008        PMID: 18216302      PMCID: PMC3664938          DOI: 10.1212/01.wnl.0000294469.27156.30

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  38 in total

1.  Simulated car crashes at intersections in drivers with Alzheimer disease.

Authors:  M Rizzo; D V McGehee; J D Dawson; S N Anderson
Journal:  Alzheimer Dis Assoc Disord       Date:  2001 Jan-Mar       Impact factor: 2.703

2.  Reliability of the Washington University Road Test. A performance-based assessment for drivers with dementia of the Alzheimer type.

Authors:  L A Hunt; C F Murphy; D Carr; J M Duchek; V Buckles; J C Morris
Journal:  Arch Neurol       Date:  1997-06

3.  Who may drive? Who may not? Who shall decide?

Authors:  D A Drachman
Journal:  Ann Neurol       Date:  1988-12       Impact factor: 10.422

4.  Crashes and violations among drivers with Alzheimer disease.

Authors:  J D Trobe; P F Waller; C A Cook-Flannagan; S M Teshima; L A Bieliauskas
Journal:  Arch Neurol       Date:  1996-05

5.  Driving in patients with dementia.

Authors:  M J Lucas-Blaustein; L Filipp; C Dungan; L Tune
Journal:  J Am Geriatr Soc       Date:  1988-12       Impact factor: 5.562

6.  The Clinical Dementia Rating (CDR): current version and scoring rules.

Authors:  J C Morris
Journal:  Neurology       Date:  1993-11       Impact factor: 9.910

7.  Longitudinal driving performance in early-stage dementia of the Alzheimer type.

Authors:  Janet M Duchek; David B Carr; Linda Hunt; Catherine M Roe; Chengjie Xiong; Kamini Shah; John C Morris
Journal:  J Am Geriatr Soc       Date:  2003-10       Impact factor: 5.562

8.  The costs and benefits of a screening program to detect dementia in older drivers.

Authors:  S M Retchin; B E Hillner
Journal:  Med Decis Making       Date:  1994 Oct-Dec       Impact factor: 2.583

9.  An examination of driving records in a dementia clinic.

Authors:  H Tuokko; K Tallman; B L Beattie; P Cooper; J Weir
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  1995-05       Impact factor: 4.077

10.  The effects of Alzheimer disease on driving-related abilities.

Authors:  G W Rebok; P M Keyl; F W Bylsma; M J Blaustein; L Tune
Journal:  Alzheimer Dis Assoc Disord       Date:  1994       Impact factor: 2.703

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  62 in total

1.  The older adult driver with cognitive impairment: "It's a very frustrating life".

Authors:  David B Carr; Brian R Ott
Journal:  JAMA       Date:  2010-04-28       Impact factor: 56.272

Review 2.  Functional Disability in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.

Authors:  Cutter A Lindbergh; Rodney K Dishman; L Stephen Miller
Journal:  Neuropsychol Rev       Date:  2016-07-08       Impact factor: 7.444

3.  Trajectories of cognitive decline by driving mobility: evidence from the Health and Retirement Study.

Authors:  Moon Choi; Matthew C Lohman; Briana Mezuk
Journal:  Int J Geriatr Psychiatry       Date:  2013-09-10       Impact factor: 3.485

4.  Clock drawing as a screen for impaired driving in aging and dementia: is it worth the time?

Authors:  Kevin J Manning; Jennifer D Davis; George D Papandonatos; Brian R Ott
Journal:  Arch Clin Neuropsychol       Date:  2013-12-01       Impact factor: 2.813

5.  Diagnosed dementia and the risk of motor vehicle crash among older drivers.

Authors:  Laura A Fraade-Blanar; Ryan N Hansen; Kwun Chuen G Chan; Jeanne M Sears; Hilaire J Thompson; Paul K Crane; Beth E Ebel
Journal:  Accid Anal Prev       Date:  2018-03-07

6.  Effects of cholinesterase inhibitors on visual attention in drivers with Alzheimer disease.

Authors:  Lori A Daiello; Brian R Ott; Elena K Festa; Michael Friedman; Lindsay A Miller; William C Heindel
Journal:  J Clin Psychopharmacol       Date:  2010-06       Impact factor: 3.153

7.  Depression and Alzheimer's Disease Biomarkers Predict Driving Decline.

Authors:  Ganesh M Babulal; Suzie Chen; Monique M Williams; Jean-Francois Trani; Parul Bakhshi; Grace L Chao; Sarah H Stout; Anne M Fagan; Tammie L S Benzinger; David M Holtzman; John C Morris; Catherine M Roe
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

Review 8.  [Assessment of ability to drive in patients with MCI and dementia].

Authors:  R Haussmann; T Wagner; D Müller; M Bauer; G Laux; M Donix
Journal:  Nervenarzt       Date:  2017-03       Impact factor: 1.214

9.  Dual-task conditions modulate the efficiency of selective attention mechanisms in Alzheimer's disease.

Authors:  Elena K Festa; William C Heindel; Brian R Ott
Journal:  Neuropsychologia       Date:  2010-07-17       Impact factor: 3.139

Review 10.  Evidence-based review of interventions for medically at-risk older drivers.

Authors:  Sherrilene Classen; Miriam Monahan; Beth Auten; Abraham Yarney
Journal:  Am J Occup Ther       Date:  2014 Jul-Aug
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