Literature DB >> 18214794

The role of genetics in Graves' disease and thyroid orbitopathy.

Nancy Kim1, Mark P Hatton.   

Abstract

Graves' disease is a complex autoimmune disorder characterized by multiple systemic manifestations of overproduction of thyroid hormone, and in some cases, orbitopathy. The etiology of this disorder is multifactorial, involving heritable abnormalities of immune regulation as well as environmental triggers. The goal of this paper is to provide a review of recent research investigating candidate genes involved in the pathophysiology of both Graves' disease per se and of thyroid orbitopathy.

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Year:  2008        PMID： 18214794     DOI： 10.1080/08820530701745256

Source DB:  PubMed          Journal:  Semin Ophthalmol        ISSN： 0882-0538            Impact factor:   1.975


  6 in total

1.  Autoimmune disease in a DFNA6/14/38 family carrying a novel missense mutation in WFS1.

Authors:  Michael S Hildebrand; Jessica L Sorensen; Maren Jensen; William J Kimberling; Richard J H Smith
Journal:  Am J Med Genet A       Date:  2008-09-01       Impact factor: 2.802

2.  Eye findings and immunological markers in probands and their euthyroid relatives from a single family with multiple cases of thyroid autoimmunity.

Authors:  Melissa Ardley; Thomas McCorquodale; Hooshang Lahooti; Bernard Champion; Jack R Wall
Journal:  Thyroid Res       Date:  2012-06-28

3.  Graves' ophthalmopathy: a review of immunogenetics.

Authors:  Omid Khalilzadeh; Sina Noshad; Armin Rashidi; Aliakbar Amirzargar
Journal:  Curr Genomics       Date:  2011-12       Impact factor: 2.236

4.  Association between polymorphisms in the TSHR gene and Graves' orbitopathy.

Authors:  Beata Jurecka-Lubieniecka; Rafal Ploski; Dorota Kula; Konrad Szymanski; Tomasz Bednarczuk; Urszula Ambroziak; Kornelia Hasse-Lazar; Lidia Hyla-Klekot; Andrzej Tukiendorf; Zofia Kolosza; Barbara Jarzab
Journal:  PLoS One       Date:  2014-07-25       Impact factor: 3.240

5.  Disturbances of modulating molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA expressions in the orbital tissue from patients with severe graves' ophthalmopathy.

Authors:  Przemyslaw Pawlowski; Natalia Wawrusiewicz-Kurylonek; Anja Eckstein; Joanna Reszec; Wlodzimierz Luczynski; Kristian Johnson; Adam Kretowski; Alina Bakunowicz-Lazarczyk; Maria Gorska; Jacek Szamatowicz; Lech Chyczewski; Janusz Mysliwiec
Journal:  Mediators Inflamm       Date:  2015-01-12       Impact factor: 4.711

Review 6.  Thyroid-Associated Orbitopathy and Biomarkers: Where We Are and What We Can Hope for the Future.

Authors:  Natacha Turck; Simone Eperon; Maria De Los Angeles Gracia; Aurélie Obéric; Mehrad Hamédani
Journal:  Dis Markers       Date:  2018-03-15       Impact factor: 3.434
  6 in total

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