PURPOSE: To investigate ability of vitamin A (VA, retinol palmitate) to promote wound healing after injury in rabbit eye. METHODS: After keratoconjunctival injury by 20 microL of n-heptanol, VA eye drops at 500, 1000, or 1500 IU/mL were started 6 times a day for 11 days. Fluorescein and rose bengal staining and histological analysis were performed. RESULTS: Fluorescein staining was significantly reduced by 1000 and 1500 IU/mL of VA and rose bengal staining by all concentrations. Histological examination revealed acceleration of wound healing after 7 days (1500 IU/mL). CONCLUSIONS: VA may be useful in treatment of keratoconjunctival injury.
PURPOSE: To investigate ability of vitamin A (VA, retinol palmitate) to promote wound healing after injury in rabbit eye. METHODS: After keratoconjunctival injury by 20 microL of n-heptanol, VA eye drops at 500, 1000, or 1500 IU/mL were started 6 times a day for 11 days. Fluorescein and rose bengal staining and histological analysis were performed. RESULTS:Fluorescein staining was significantly reduced by 1000 and 1500 IU/mL of VA and rose bengal staining by all concentrations. Histological examination revealed acceleration of wound healing after 7 days (1500 IU/mL). CONCLUSIONS:VA may be useful in treatment of keratoconjunctival injury.
Authors: Dae Won Kim; Sung Ho Lee; Min Jea Shin; Kibom Kim; Sae Kwang Ku; Jong Kyu Youn; Su Bin Cho; Jung Hwan Park; Chi Hern Lee; Ora Son; Eun Jeong Sohn; Sung-Woo Cho; Jong Hoon Park; Hyun Ah Kim; Kyu Hyung Han; Jinseu Park; Won Sik Eum; Soo Young Choi Journal: BMB Rep Date: 2015-11 Impact factor: 4.778