Literature DB >> 18214642

Silk sericin protein of tropical tasar silkworm inhibits UVB-induced apoptosis in human skin keratinocytes.

Rupesh Dash1, Mahitosh Mandal, Sudip K Ghosh, S C Kundu.   

Abstract

The silk protein sericin has been identified as a potent antioxidant and photoprotective agent against ultraviolet B (UVB) irradiation in mouse skin model. In this study, we have investigated the anti-apoptotic effect of sericin in UVB (30 mJ/cm2)-irradiated human keratinocytes. Flow cytometry analysis has shown that pre-treatment with sericin inhibits UVB-induced apoptosis. The pre-treatment with sericin suppresses bax expression, up-regulates the expression of bcl-2, prevents both the activation of caspase-3 and cleavage of Poly (ADP-ribose) polymerase. Generation of intracellular hydrogen peroxide in UVB-treated keratinocytes is inhibited through pre-treatment with sericin suggesting that sericin probably prevents mitochondrial damage.

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Year:  2008        PMID： 18214642     DOI： 10.1007/s11010-008-9702-z

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  31 in total

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Authors:  Rupesh Dash; Sudip K Ghosh; David L Kaplan; S C Kundu
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Review 10.  Independent contribution of three different pathways to ultraviolet-B-induced apoptosis.

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Journal:  Biochem Pharmacol       Date:  2002-09       Impact factor: 5.858
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