Literature DB >> 18214499

[Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients].

W K Aicher1, T Pap, S Gay.   

Abstract

Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18214499     DOI： 10.1007/s00393-008-0261-1

Source DB:  PubMed          Journal:  Z Rheumatol        ISSN： 0340-1855            Impact factor:   1.372


  7 in total

1.  NF-kappaB: Holy Grail for rheumatoid arthritis?

Authors:  Gary S Firestein
Journal:  Arthritis Rheum       Date:  2004-08

Review 2.  Matrix metalloproteinases: role in arthritis.

Authors:  Peter S Burrage; Kimberlee S Mix; Constance E Brinckerhoff
Journal:  Front Biosci       Date:  2006-01-01

Review 3.  Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?

Authors:  S Gay; R E Gay; W J Koopman
Journal:  Ann Rheum Dis       Date:  1993-03       Impact factor: 19.103

4.  Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts.

Authors:  Maik Hoberg; Maximilian Rudert; Thomas Pap; Gerd Klein; Steffen Gay; Wilhelm K Aicher
Journal:  Ann Rheum Dis       Date:  2006-11-23       Impact factor: 19.103

5.  Soluble tumour necrosis factor receptor treatment does not affect raised transforming growth factor beta levels in rheumatoid arthritis.

Authors:  S Drynda; C Kühne; J Kekow
Journal:  Ann Rheum Dis       Date:  2002-03       Impact factor: 19.103

Review 6.  Fibroblast biology. Role of synovial fibroblasts in the pathogenesis of rheumatoid arthritis.

Authors:  T Pap; U Müller-Ladner; R E Gay; S Gay
Journal:  Arthritis Res       Date:  2000-06-08

Review 7.  New insights into integrin signalling: implications for rheumatoid arthritis synovial fibroblasts.

Authors:  Thomas Pap
Journal:  Arthritis Res Ther       Date:  2003-04-10       Impact factor: 5.156
  7 in total
  2 in total

1.  Laminin induces matrix metalloproteinase-9 expression and activation in human cervical cancer cell line (SiHa).

Authors:  Gargi Maity; Triparna Sen; Amitava Chatterjee
Journal:  J Cancer Res Clin Oncol       Date:  2010-04-28       Impact factor: 4.553

2.  Proinflammatory and Anabolic Gene Expression Effects of Platelet-Rich Gel Supernatants on Equine Synovial Membrane Explants Challenged with Lipopolysaccharide.

Authors:  Jorge U Carmona; Diana L Ríos; Catalina López; María E Álvarez; Jorge E Pérez
Journal:  Vet Med Int       Date:  2017-07-06
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.