Literature DB >> 18214302

Effect of histochrome on brain vessels and research and exploratory activity of senescence-accelerated OXYS rats.

I G Agafonova1, N G Kolosova, N P Mishchenko, E L Chaikina, V A Stonik.   

Abstract

Changes in the diameter of brain vessels and intensity of collateral blood flow typical of chronic ischemia were detected by magnetic resonance imaging in senescence-accelerated OXYS rats demonstrating reduced (compared to Wistar rats) research and exploratory activity. Histochrome (antioxidant drug) produced positive effects on cerebral vessels in OXYS rats by stimulating collateral blood flow and acting as a vasodilator agent. Analysis of correlations showed that these effects of histochrome were closely related to its capacity to activate research and exploratory activity and reduce anxiety of OXYS rats in the open field test.

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Year:  2007        PMID： 18214302     DOI： 10.1007/s10517-007-0158-z

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

Review 1.  Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease.

Authors:  Natalia A Stefanova; Oyuna S Kozhevnikova; Anton O Vitovtov; Kseniya Yi Maksimova; Sergey V Logvinov; Ekaterina A Rudnitskaya; Elena E Korbolina; Natalia A Muraleva; Nataliya G Kolosova
Journal:  Cell Cycle       Date:  2014-02-17       Impact factor: 4.534

2.  Association of cerebrovascular dysfunction with the development of Alzheimer's disease-like pathology in OXYS rats.

Authors:  Natalia A Stefanova; Kseniya Yi Maksimova; Ekaterina A Rudnitskaya; Natalia A Muraleva; Nataliya G Kolosova
Journal:  BMC Genomics       Date:  2018-02-09       Impact factor: 3.969

3.  Suppression of Alzheimer's Disease-Like Pathology Progression by Mitochondria-Targeted Antioxidant SkQ1: A Transcriptome Profiling Study.

Authors:  Natalia A Stefanova; Nikita I Ershov; Nataliya G Kolosova
Journal:  Oxid Med Cell Longev       Date:  2019-07-15       Impact factor: 6.543

Review 4.  Multifaceted Clinical Effects of Echinochrome.

Authors:  Hyoung Kyu Kim; Elena A Vasileva; Natalia P Mishchenko; Sergey A Fedoreyev; Jin Han
Journal:  Mar Drugs       Date:  2021-07-26       Impact factor: 5.118

5.  Modulation of the expression of genes related to the system of amyloid-beta metabolism in the brain as a novel mechanism of ceftriaxone neuroprotective properties.

Authors:  Maria A Tikhonova; Tamara G Amstislavskaya; Victor M Belichenko; Larisa A Fedoseeva; Sergey P Kovalenko; Ekaterina E Pisareva; Alla S Avdeeva; Nataliya G Kolosova; Nikolai D Belyaev; Lyubomir I Aftanas
Journal:  BMC Neurosci       Date:  2018-04-19       Impact factor: 3.288
  5 in total

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