| Literature DB >> 18214301 |
A V Vaiman1, T P Stromskaya, E Yu Rybalkina, A V Sorokin, L P Ovchinnikov, A A Stavrovskaya.
Abstract
The effects of YB-1 gene on the expression level of P-glycoprotein and drug resistance of tumor cells were studied in cultured HCT116 colon cancer cells. Transitory transfection of chimeric YB-1/GFP gene rendered HCT116 cells a selective advantage in a medium with vinblastine, which caused translocation of the chimeric protein into cell nuclei. This was paralleled by an increase in the expression of P-glycoprotein (multiple drug resistance protein).Entities:
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Year: 2007 PMID： 18214301 DOI： 10.1007/s10517-007-0157-0
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804