BACKGROUND: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. PATIENTS AND METHODS: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. RESULTS: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. CONCLUSION: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.
BACKGROUND: Although a number of studies on the polymorphisms in COX1 and COX2 genes in association with risks for a number of cancers have been conducted, their relation to gastric cancer has not been well studied. PATIENTS AND METHODS: Genotypes of several variants in both COX1 (Ex7+31 C>A and Ex10-4 G>A) and COX2 (-765 G>C, Ex10+837 T>C, Ex10-90 C>T, IVS5-275 T>G, and IVS7+111 T>C) were identified by TaqMan assays in 305 gastric cancer cases and 427 age- and gender-matched controls in a high-risk Polish population. Odds ratios for gastric cancer and 95% confidence intervals from unconditional logistic regression models were used to evaluate relative risks. RESULTS: We found no statistically significant evidence that the polymorphisms tested in COX1 and COX2 are associated with gastric cancer risk. CONCLUSION: These results suggest that the polymorphisms examined in COX1 and COX2 do not affect the risk of gastric cancer.
Authors: In Jai Kim; Sang Hoon Kim; Dong Hoon Cha; Sang Wook Lim; Jae Youn Moon; Jung Oh Kim; Chang Soo Ryu; Han Sung Park; Jung Hoon Sung; Nam Keun Kim Journal: Genes Genomics Date: 2019-06-05 Impact factor: 1.839
Authors: Diogo N Piranda; Juliana S Festa-Vasconcellos; Laura M Amaral; Anke Bergmann; Rosane Vianna-Jorge Journal: BMC Cancer Date: 2010-11-08 Impact factor: 4.430