BACKGROUND/AIMS: We investigated whether an initial neuropsychological assessment could predict rapid progression over 12 months, from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). METHODS: A longitudinal study compared the neuropsychological profiles of 27 normal controls and 18 aMCI patients at baseline and 12 months. RESULTS: At 12 months, 24 control subjects followed up remained cognitively normal. 7 aMCI patients (6 multiple-domain aMCI and 1 single-domain aMCI) progressed to AD, and 11 were non-progressors. Prognosis was best captured by a combination of associative learning, the paired associate learning task (PAL), and global cognition, the Addenbrooke's Cognitive Examination (ACE). CONCLUSION: The PAL and ACE can sensitively detect meaningful differences in scores at baseline and may be used as prognostic indicators. Multiple-domain aMCI patients progressed rapidly to AD and may be more usefully labelled as early stage AD. Copyright (c) 2008 S. Karger AG, Basel.
BACKGROUND/AIMS: We investigated whether an initial neuropsychological assessment could predict rapid progression over 12 months, from amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). METHODS: A longitudinal study compared the neuropsychological profiles of 27 normal controls and 18 aMCIpatients at baseline and 12 months. RESULTS: At 12 months, 24 control subjects followed up remained cognitively normal. 7 aMCIpatients (6 multiple-domain aMCI and 1 single-domain aMCI) progressed to AD, and 11 were non-progressors. Prognosis was best captured by a combination of associative learning, the paired associate learning task (PAL), and global cognition, the Addenbrooke's Cognitive Examination (ACE). CONCLUSION: The PAL and ACE can sensitively detect meaningful differences in scores at baseline and may be used as prognostic indicators. Multiple-domain aMCIpatients progressed rapidly to AD and may be more usefully labelled as early stage AD. Copyright (c) 2008 S. Karger AG, Basel.
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Authors: Mili Parikh; Linda S Hynan; Myron F Weiner; Laura Lacritz; Wendy Ringe; C Munro Cullum Journal: Clin Neuropsychol Date: 2014-08-18 Impact factor: 3.535
Authors: Thomas Polak; Martin J Herrmann; Laura D Müller; Julia B M Zeller; Andrea Katzorke; Matthias Fischer; Fabian Spielmann; Erik Weinmann; Leif Hommers; Martin Lauer; Andreas J Fallgatter; Jürgen Deckert Journal: J Neural Transm (Vienna) Date: 2017-09-01 Impact factor: 3.575
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